CCPG1: Cell Cycle Progression 1
A gene encoding a protein involved in cell cycle regulation and potential tumor suppression.
Gene Information Card
| Symbol | CCPG1 |
|---|---|
| Full Name | Cell Cycle Progression 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 15q21.1 |
| NCBI Gene ID | 9236 ncbi.nlm.nih.gov/gene/9236 |
| Ensembl ID | ENSG00000137807 |
| UniProt ID | Q9H6Z9 |
| OMIM ID | 611152 |
| HGNC ID | 24227 |
| Aliases | C15orf2, FLJ12787, MGC138290 |
Description
CCPG1 (Cell Cycle Progression 1) is a protein-coding gene located on chromosome 15q21.1. It encodes a protein involved in cell cycle regulation, particularly in the G1/S transition. The protein contains a cyclin-like domain and may function as a tumor suppressor. Altered expression has been observed in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered CCPG1 expression may disrupt cell cycle control, promoting proliferation. | Low expression in breast tumors (NCBI GEO profiles). |
| Colorectal cancer | Downregulation of CCPG1 correlates with poor prognosis and increased cell proliferation. | COSMIC mutation data; reduced expression in tumor samples. |
| Lung cancer | Mutations and reduced expression of CCPG1 may contribute to tumorigenesis. | COSMIC; ClinVar variant reports. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.3 | Low |
| Lymph node | 6.1 | Low |
| Brain | 4.2 | Low |
| Breast | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | Embryonic kidney cell line |
| HeLa | 10.5 | Cervical cancer cell line |
| MCF7 | 7.8 | Breast cancer cell line |
| A549 | 5.3 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339*) | Nonsense | <0.1% | Premature stop; loss of function |
| c.742G>A (p.Gly248Arg) | Missense | <0.1% | Unknown functional impact |
| c.1234_1235insA | Frameshift | <0.1% | Frameshift; likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Arg339*, c.1234_1235insA) are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No gain-of-function mutations have been reported for CCPG1.
Dominant Negative (DN)
No dominant-negative mutations have been described for CCPG1.
View complete mutation data：
Gene Ontology (GO)
| • cell cycle | • G1/S transition of mitotic cell cycle |
| • cyclin-dependent protein serine/threonine kinase regulator activity | • nucleus |
| • cytoplasm |
Pathways
• Cell Cycle
• G1 to S cell cycle control
Protein Summary
The CCPG1 protein (UniProt Q9H6Z9) is 789 amino acids long and contains a cyclin-like domain. It is localized in the nucleus and cytoplasm and is involved in regulating the G1/S transition of the cell cycle. The protein may act as a tumor suppressor by controlling cell proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCPG1 Knockout HEK293 Cell Line | EDJ-KQ6514 | Human | 9236 | Details Get a Quote |
| CCPG1 Knockout A-549 Cell Line | EDJ-KQ30659 | Human | 9236 | Details Get a Quote |
| CCPG1 Knockout HCT 116 Cell Line | EDJ-KQ30660 | Human | 9236 | Details Get a Quote |
| CCPG1 Knockout HeLa Cell Line | EDJ-KQ30661 | Human | 9236 | Details Get a Quote |
