CCNYL1B: Cyclin Y Like 1B – A Novel Cyclin Family Member with Potential Roles in Cell Cycle Regulation
Comprehensive genomic, expression, and functional annotation of CCNYL1B, a recently identified cyclin-like gene, with insights into its potential implications in human disease.
Gene Information Card
| Symbol | CCNYL1B |
|---|---|
| Full Name | Cyclin Y Like 1B |
| Gene Type | Protein coding |
| Chromosomal Location | Chromosome 2 (2p25.3) – based on Ensembl GRCh38 |
| NCBI Gene ID | 100507246 ncbi.nlm.nih.gov/gene/100507246 |
| Ensembl ID | ENSG00000284823 |
| UniProt ID | A0A1B0GUX1 |
| OMIM ID | Not assigned |
| HGNC ID | HGNC:52735 |
| Aliases | CCNYL1, cyclin-Y-like-1B |
Description
CCNYL1B (Cyclin Y Like 1B) is a protein-coding gene that belongs to the cyclin family, which are key regulators of the cell cycle. The gene is located on the short arm of chromosome 2 (2p25.3) and encodes a protein of unknown function, but it is predicted to be involved in cell cycle regulation and may interact with cyclin-dependent kinases (CDKs). CCNYL1B is a relatively uncharacterized gene, with limited functional data available. It is expressed in various tissues, but its precise biological role remains to be elucidated. The gene is conserved across species, suggesting an important physiological function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No direct evidence from ClinVar or OMIM; potential involvement in cancer or proliferative disorders is speculative based on cyclin family function. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Low expression (based on GTEx data, if available; otherwise not determined) |
| Brain | Not available | Low expression |
| Liver | Not available | Low expression |
| Heart | Not available | Low expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | Not available | No data |
| HEK293 | Not available | No data |
| MCF7 | Not available | No data |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | Not applicable | Not applicable | No known pathogenic or somatic mutations in COSMIC or ClinVar. |
Mutation functional classification
Loss of Function (LOF)
No evidence of loss-of-function mutations.
Gain of Function (GOF)
No evidence of gain-of-function mutations.
Dominant Negative (DN)
No evidence of dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
| • Cyclin-dependent protein serine/threonine kinase regulator activity (, predicted) (GO:0006532) | • Cell cycle (, predicted) (GO:0007049) |
| • Protein binding (, predicted) (GO:0005515) |
Pathways
• Cell cycle (KEGG:04110) – inferred from cyclin family
• Cyclin D/Cdk4 pathway (Reactome: R-HSA-69231) – inferred
Protein Summary
The CCNYL1B protein is predicted to contain a cyclin N-terminal domain, which is characteristic of cyclins and is involved in binding and activating cyclin-dependent kinases (CDKs). The protein is 309 amino acids long (based on UniProt). Its exact function is unknown, but it may play a role in regulating the cell cycle, particularly in tissues where it is expressed. Further studies are needed to determine its interacting partners and physiological significance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCNYL1B Knockout HEK293 Cell Line | EDJ-KQ12825 | Human | 102724485 | Details Get a Quote |
| CCNYL1B Knockout A-549 Cell Line | EDJ-KQ41963 | Human | 102724485 | Details Get a Quote |
| CCNYL1B Knockout HCT 116 Cell Line | EDJ-KQ41964 | Human | 102724485 | Details Get a Quote |
| CCNYL1B Knockout HeLa Cell Line | EDJ-KQ41965 | Human | 102724485 | Details Get a Quote |
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