CCNI (Cyclin I)
A cyclin family member involved in cell cycle regulation and transcriptional control
Gene Information Card
| Symbol | CCNI |
|---|---|
| Full Name | Cyclin I |
| Gene Type | Protein coding |
| Chromosomal Location | 4q21.1 |
| NCBI Gene ID | 10983 ncbi.nlm.nih.gov/gene/10983 |
| Ensembl ID | ENSG00000138668 |
| UniProt ID | Q14094 |
| OMIM ID | 603782 |
| HGNC ID | 1595 |
| Aliases | CYCI, CCNI1 |
Description
CCNI encodes Cyclin I, a member of the cyclin family that regulates cell cycle progression and transcription. Cyclin I is expressed in various tissues and is involved in cyclin-dependent kinase (CDK) activation, particularly CDK5 and CDK2. It plays roles in neuronal development, cell differentiation, and apoptosis. Aberrant expression has been linked to cancer and neurodegenerative disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered CCNI expression may disrupt cell cycle control and promote proliferation | NCBI Gene, COSMIC |
| Neurodegenerative disorders | Cyclin I interacts with CDK5; dysregulation implicated in neuronal death | UniProt, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Lung | 6.7 | Low |
| Liver | 4.2 | Low |
| Kidney | 7.1 | Low |
| Testis | 15.0 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.2 | Cervical cancer cell line |
| HEK293 | 8.5 | Embryonic kidney cells |
| SH-SY5Y | 14.0 | Neuroblastoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | Missense | <0.1% | Unknown functional impact |
| c.456G>A | Synonymous | <0.1% | No predicted effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • cyclin-dependent protein serine/threonine kinase regulator activity | • protein binding |
| • cell cycle | • regulation of cell cycle |
| • nucleus | • cytoplasm |
Pathways
• Cell Cycle
• CDK-mediated phosphorylation and removal of Cdc6
• Apoptosis
Protein Summary
Cyclin I is a 45 kDa protein containing a cyclin box domain. It binds and activates CDK5 and CDK2, influencing cell cycle progression and neuronal function. The protein is localized in the nucleus and cytoplasm, with highest expression in brain and testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCNI Knockout HEK293 Cell Line | EDJ-KQ3086 | Human | 10983 | Details Get a Quote |
| CCNI2 Knockout HEK293 Cell Line | EDJ-KQ12821 | Human | 645121 | Details Get a Quote |
| CCNI Knockout A-549 Cell Line | EDJ-KQ24391 | Human | 10983 | Details Get a Quote |
| CCNI Knockout HCT 116 Cell Line | EDJ-KQ24392 | Human | 10983 | Details Get a Quote |
| CCNI Knockout HeLa Cell Line | EDJ-KQ24393 | Human | 10983 | Details Get a Quote |
| CCNI2 Knockout HeLa Cell Line | EDJ-KQ60581 | Human | 645121 | Details Get a Quote |
| CCNI2 Knockout A-549 Cell Line | EDJ-KQ69051 | Human | 645121 | Details Get a Quote |
| CCNI2 Knockout HCT 116 Cell Line | EDJ-KQ77406 | Human | 645121 | Details Get a Quote |
