CCNDBP1
Cyclin D1 Binding Protein 1
Gene Information Card
| Symbol | CCNDBP1 |
|---|---|
| Full Name | Cyclin D1 Binding Protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 15q23 |
| NCBI Gene ID | 23582 ncbi.nlm.nih.gov/gene/23582 |
| Ensembl ID | ENSG00000137807 |
| UniProt ID | O95273 |
| OMIM ID | 607139 |
| HGNC ID | 2037 |
| Aliases | DIP1, HCGV, GCIP, hGCIP, MAK10, MAK10P, MAK10L |
Description
CCNDBP1 encodes a protein that binds to cyclin D1 and functions as a negative regulator of cell cycle progression. It is involved in transcriptional regulation and may play a role in growth control and differentiation. The protein interacts with cyclin D1 and inhibits its activity, thereby modulating cell proliferation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression of CCNDBP1 may affect cyclin D1-mediated cell cycle regulation, contributing to tumorigenesis. | PMID: 14502222 |
| Colorectal cancer | Reduced CCNDBP1 expression correlates with poor prognosis and increased proliferation. | PMID: 19165227 |
| Hepatocellular carcinoma | Downregulation of CCNDBP1 is associated with tumor progression and metastasis. | PMID: 21804532 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.7 | Medium |
| Lung | 6.5 | Low |
| Liver | 4.2 | Low |
| Heart | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | High expression |
| HeLa | 10.8 | Medium expression |
| MCF7 | 7.5 | Medium expression |
| HepG2 | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.215C>T | missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • nucleus (GO:0005634) |
| • cytoplasm (GO:0005737) | • identical protein binding (GO:0042802) |
| • positive regulation of transcription by RNA polymerase II (GO:0045944) |
Pathways
• Cell cycle - KEGG hsa04110
• Transcriptional misregulation in cancer - KEGG hsa05202
Protein Summary
The CCNDBP1 protein (UniProt O95273) is a 729-amino acid protein that localizes to the nucleus and cytoplasm. It contains a cyclin D1 binding domain and functions as a transcriptional co-regulator. The protein is involved in cell cycle control and may act as a tumor suppressor by inhibiting cyclin D1 activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCNDBP1 Knockout HEK293 Cell Line | EDJ-KQ8084 | Human | 23582 | Details Get a Quote |
| CCNDBP1 Knockout A-549 Cell Line | EDJ-KQ33929 | Human | 23582 | Details Get a Quote |
| CCNDBP1 Knockout HCT 116 Cell Line | EDJ-KQ33930 | Human | 23582 | Details Get a Quote |
| CCNDBP1 Knockout HeLa Cell Line | EDJ-KQ33931 | Human | 23582 | Details Get a Quote |
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