CCDC87 Gene: Coiled-Coil Domain Containing 87 - Function, Disease Associations, and Expression
Comprehensive biomedical overview of CCDC87, including genomic context, expression profiles, mutations, and functional annotations.
Gene Information Card
| Symbol | CCDC87 |
|---|---|
| Full Name | Coiled-Coil Domain Containing 87 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q23.3 |
| NCBI Gene ID | 152940 ncbi.nlm.nih.gov/gene/152940 |
| Ensembl ID | ENSG00000187608 |
| UniProt ID | Q6ZP82 |
| OMIM ID | Not available |
| HGNC ID | HGNC:26726 |
| Aliases | FLJ46365 |
Description
CCDC87 (coiled-coil domain containing 87) is a protein-coding gene located on chromosome 11q23.3. It encodes a protein of unknown function, characterized by coiled-coil domains. Expression data suggest broad but variable tissue distribution. Currently, no disease associations have been firmly established, and the gene is not listed in OMIM. It is included in major genomic databases but lacks extensive functional characterization.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No confirmed disease associations | Not established | No curated disease links in OMIM or ClinVar as of current knowledge. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Not determined |
| Thyroid | Not available | Not determined |
| Lung | Not available | Not determined |
| Kidney | Not available | Not determined |
| Brain | Not available | Not determined |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line data available | Not available | No expression data from major databases. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | Not available | Not available | No pathogenic or somatic mutations reported in ClinVar or COSMIC. |
Mutation functional classification
Loss of Function (LOF)
No evidence of loss-of-function mutations or phenotypes.
Gain of Function (GOF)
No evidence of gain-of-function mutations.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • No GO terms annotated for CCDC87 in UniProt or Ensembl. |
Pathways
• No known pathways associated with CCDC87.
Protein Summary
The CCDC87 protein is predicted to contain coiled-coil domains, suggesting potential involvement in protein-protein interactions or structural roles. However, its exact function remains unknown. No post-translational modifications or subcellular localization have been experimentally characterized. The protein is predicted to be intracellular, but no experimental validation exists.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCDC87 Knockout HEK293 Cell Line | EDJ-KQ12767 | Human | 55231 | Details Get a Quote |
| CCDC87 Knockout HeLa Cell Line | EDJ-KQ56560 | Human | 55231 | Details Get a Quote |
| CCDC87 Knockout A-549 Cell Line | EDJ-KQ65055 | Human | 55231 | Details Get a Quote |
| CCDC87 Knockout HCT 116 Cell Line | EDJ-KQ73500 | Human | 55231 | Details Get a Quote |
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