CCDC77
Coiled-Coil Domain Containing 77
Gene Information Card
| Symbol | CCDC77 |
|---|---|
| Full Name | Coiled-Coil Domain Containing 77 |
| Gene Type | Protein coding |
| Chromosomal Location | 12p13.33 |
| NCBI Gene ID | 64777 ncbi.nlm.nih.gov/gene/64777 |
| Ensembl ID | ENSG00000111206 |
| UniProt ID | Q9BQI5 |
| OMIM ID | 617690 |
| HGNC ID | 26792 |
| Aliases | FLJ12606, MGC13170 |
Description
CCDC77 encodes a protein containing a coiled-coil domain, which is often involved in protein-protein interactions. The gene is located on chromosome 12p13.33 and is expressed in various tissues. Its specific biological function is not fully characterized, but it may play a role in cellular structure or signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 8.2 | Low |
| Lung | 6.1 | Low |
| Brain | 4.3 | Low |
| Liver | 3.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.0 | Embryonic kidney |
| HeLa | 7.5 | Cervical carcinoma |
| K562 | 5.2 | Leukemia |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Gene Ontology (GO)
| • Protein binding (GO:0005515) |
Protein Summary
The CCDC77 protein (UniProt Q9BQI5) contains a coiled-coil domain, suggesting involvement in protein-protein interactions. Its exact function remains unclear, and no disease-associated variants have been reported.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCDC77 Knockout HEK293 Cell Line | EDJ-KQ10066 | Human | 84318 | Details Get a Quote |
| CCDC77 Knockout A-549 Cell Line | EDJ-KQ37114 | Human | 84318 | Details Get a Quote |
| CCDC77 Knockout HCT 116 Cell Line | EDJ-KQ37115 | Human | 84318 | Details Get a Quote |
| CCDC77 Knockout HeLa Cell Line | EDJ-KQ37116 | Human | 84318 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
