CCDC74B: Coiled-Coil Domain Containing 74B
A gene encoding a coiled-coil domain-containing protein with potential roles in cellular organization and signaling.
Gene Information Card
| Symbol | CCDC74B |
|---|---|
| Full Name | Coiled-Coil Domain Containing 74B |
| Gene Type | Protein-coding |
| Chromosomal Location | 2q37.3 |
| NCBI Gene ID | 91409 ncbi.nlm.nih.gov/gene/91409 |
| Ensembl ID | ENSG00000163083 |
| UniProt ID | Q96M27 |
| OMIM ID | Not available |
| HGNC ID | 26119 |
| Aliases | FLJ20674, MGC13170 |
Description
CCDC74B (Coiled-Coil Domain Containing 74B) is a protein-coding gene located on chromosome 2q37.3. The encoded protein contains a coiled-coil domain, which is often involved in protein-protein interactions, cytoskeletal organization, and intracellular signaling. The specific biological function of CCDC74B remains largely uncharacterized, but it may play roles in cellular architecture and signal transduction.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.0 | Moderate expression |
| HeLa | 7.5 | Low expression |
| K562 | 6.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) |
Protein Summary
The CCDC74B protein (UniProt Q96M27) is 374 amino acids long and contains a coiled-coil domain. Its exact function is unknown, but it may participate in protein-protein interactions and cellular organization. No structural or functional studies have been published.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCDC74B Knockout HEK293 Cell Line | EDJ-KQ10731 | Human | 91409 | Details Get a Quote |
| CCDC74B Knockout A-549 Cell Line | EDJ-KQ38303 | Human | 91409 | Details Get a Quote |
| CCDC74B Knockout HCT 116 Cell Line | EDJ-KQ38304 | Human | 91409 | Details Get a Quote |
| CCDC74B Knockout HeLa Cell Line | EDJ-KQ38305 | Human | 91409 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
