CCDC198
Coiled-Coil Domain Containing 198
Gene Information Card
| Symbol | CCDC198 |
|---|---|
| Full Name | Coiled-Coil Domain Containing 198 |
| Gene Type | protein-coding |
| Chromosomal Location | 14q32.33 |
| NCBI Gene ID | 100130449 ncbi.nlm.nih.gov/gene/100130449 |
| Ensembl ID | ENSG00000267280 |
| UniProt ID | A0A1B0GTV8 |
| OMIM ID | - |
| HGNC ID | HGNC:37226 |
| Aliases | MGC16384, FLJ45803 |
Description
CCDC198 is a protein-coding gene located on chromosome 14q32.33. It encodes a protein containing a coiled-coil domain, which is often involved in protein-protein interactions and structural functions. The specific biological role of CCDC198 is not yet fully characterized, but it is predicted to be involved in cellular processes such as cytoskeletal organization or signaling. Expression data suggest low to moderate levels in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No established disease associations | - | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.5 | Low |
| Brain | 1.2 | Low |
| Lung | 0.8 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 1.0 | Low expression |
| HeLa | 0.6 | Not detected |
| K562 | 0.3 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | - | - | - |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • identical protein binding (GO:0042802) |
Pathways
• No curated pathways available
Protein Summary
The CCDC198 protein is predicted to contain a coiled-coil domain, suggesting a role in mediating protein-protein interactions. Its exact function remains unknown, and no significant disease associations have been reported.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCDC198 Knockout HEK293 Cell Line | EDJ-KQ12809 | Human | 55195 | Details Get a Quote |
| CCDC198 Knockout A-549 Cell Line | EDJ-KQ41942 | Human | 55195 | Details Get a Quote |
| CCDC198 Knockout HeLa Cell Line | EDJ-KQ56551 | Human | 55195 | Details Get a Quote |
| CCDC198 Knockout HCT 116 Cell Line | EDJ-KQ73492 | Human | 55195 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
