CAPN15: Calpain 15
A non-lysosomal cysteine protease involved in cellular signaling and development
Gene Information Card
| Symbol | CAPN15 |
|---|---|
| Full Name | calpain 15 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 6650 ncbi.nlm.nih.gov/gene/6650 |
| Ensembl ID | ENSG00000103197 |
| UniProt ID | O75808 |
| OMIM ID | 602267 |
| HGNC ID | 1479 |
| Aliases | SOLH, CANP15, calpain-15, small optic lobes homolog |
Description
CAPN15 (calpain 15) is a protein-coding gene that encodes a member of the calpain family of intracellular cysteine proteases. The protein contains a calpain catalytic domain and a C-terminal domain homologous to the Drosophila small optic lobes (SOL) protein, suggesting a role in neuronal development and function. CAPN15 is involved in proteolytic processing of target proteins, regulating cellular processes such as cell cycle, differentiation, and apoptosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered expression and activity of CAPN15 may contribute to tumor progression through dysregulation of proteolytic signaling. | COSMIC; PMID: 23549388 |
| Breast cancer | CAPN15 mutations and expression changes have been observed in breast cancer samples, potentially affecting cell adhesion and migration. | COSMIC; PMID: 25691885 |
| Lung cancer | Somatic mutations in CAPN15 have been identified in lung adenocarcinoma, with possible impact on cell survival pathways. | COSMIC; PMID: 22980975 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 4.2 | Low |
| Testis | 3.8 | Low |
| Lung | 2.1 | Low |
| Colon | 1.5 | Low |
| Breast | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 2.5 | Embryonic kidney cells |
| HeLa | 1.8 | Cervical cancer cells |
| A549 | 1.6 | Lung cancer cells |
| MCF7 | 1.4 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.1% | Unknown functional effect; reported in COSMIC |
| c.567_568del (p.Glu189fs) | Frameshift | <0.1% | Predicted loss of function |
| c.890A>G (p.Asn297Ser) | Missense | <0.1% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No gain-of-function mutations have been reported for CAPN15.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for CAPN15.
View complete mutation data：
Gene Ontology (GO)
| • calcium-dependent cysteine-type endopeptidase activity (GO:0004198) | • proteolysis (GO:0006508) |
| • nucleus (GO:0005634) | • cytoplasm (GO:0005737) |
| • nervous system development (GO:0007399) |
Pathways
• Calpain proteolysis pathway (Reactome: R-HSA-5625740)
• Apoptosis-related proteolysis (Reactome: R-HSA-109581)
Protein Summary
Calpain 15 (CAPN15) is a 729-amino acid calcium-dependent cysteine protease. It contains a catalytic domain typical of calpains and a unique C-terminal SOLH domain. The protein is expressed in multiple tissues, with highest levels in brain and testis. It is involved in limited proteolysis of substrates, influencing cell signaling, cytoskeletal remodeling, and development. Mutations in CAPN15 are rare but have been reported in various cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CAPN15 Knockout HEK293 Cell Line | EDJ-KQ5830 | Human | 6650 | Details Get a Quote |
| CAPN15 Knockout HCT 116 Cell Line | EDJ-KQ28010 | Human | 6650 | Details Get a Quote |
| CAPN15 Knockout A-549 Cell Line | EDJ-KQ29268 | Human | 6650 | Details Get a Quote |
| CAPN15 Knockout HeLa Cell Line | EDJ-KQ29270 | Human | 6650 | Details Get a Quote |
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