CADM3: Cell Adhesion Molecule 3
A member of the immunoglobulin superfamily involved in cell-cell adhesion and tumor suppression
Gene Information Card
| Symbol | CADM3 |
|---|---|
| Full Name | Cell Adhesion Molecule 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q21.2 |
| NCBI Gene ID | 57863 ncbi.nlm.nih.gov/gene/57863 |
| Ensembl ID | ENSG00000162706 |
| UniProt ID | Q8N6C5 |
| OMIM ID | 609935 |
| HGNC ID | 17601 |
| Aliases | TSLC1-like, IgSF4C, NECL1, SynCAM3, IGSF4C |
Description
CADM3 (Cell Adhesion Molecule 3) encodes a member of the immunoglobulin superfamily. The protein is a transmembrane cell adhesion molecule that mediates homophilic and heterophilic cell-cell interactions. It is involved in neuronal synapse organization, tumor suppression, and epithelial integrity. CADM3 is also known as TSLC1-like, IgSF4C, NECL1, and SynCAM3.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Loss of CADM3 expression may contribute to tumor progression through reduced cell adhesion | PMID: 15674384 |
| Colorectal cancer | Downregulation of CADM3 associated with metastasis and poor prognosis | PMID: 21145473 |
| Autism spectrum disorder | Rare variants in CADM3 implicated in synaptic dysfunction | ClinVar: VCV000429496 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Kidney | 6.1 | Low |
| Testis | 15.2 | Medium |
| Heart | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 18.4 | Neuronal expression |
| A549 (lung carcinoma) | 2.1 | Low expression |
| HEK293 (embryonic kidney) | 5.6 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown significance |
| c.457G>A (p.Gly153Arg) | Missense | <0.01% | Likely benign |
| c.1234C>T (p.Arg412*) | Nonsense | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg412*) lead to truncated protein and loss of adhesion function.
Gain of Function (GOF)
No gain-of-function mutations reported in CADM3.
Dominant Negative (DN)
No dominant-negative mutations described for CADM3.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion (GO:0007155) | • plasma membrane (GO:0005886) |
| • synapse (GO:0045202) | • homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156) |
| • cell junction (GO:0030054) |
Pathways
• Cell adhesion molecules (CAMs) - KEGG hsa04514
• Adherens junction - KEGG hsa04520
Protein Summary
CADM3 is a 445-amino acid transmembrane glycoprotein with three extracellular immunoglobulin-like domains (one V-type, two C2-type) and a short cytoplasmic tail. It mediates homophilic and heterophilic adhesion with other CADM family members. The protein is highly expressed in brain and testis, and plays roles in synapse formation, neurite outgrowth, and tumor suppression. Loss of CADM3 expression is observed in several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CADM3 Knockout HEK293 Cell Line | EDJ-KQ3661 | Human | 57863 | Details Get a Quote |
| CADM3 Knockout HeLa Cell Line | EDJ-KQ56928 | Human | 57863 | Details Get a Quote |
| CADM3 Knockout A-549 Cell Line | EDJ-KQ65433 | Human | 57863 | Details Get a Quote |
| CADM3 Knockout HCT 116 Cell Line | EDJ-KQ73871 | Human | 57863 | Details Get a Quote |
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