CAB39L: Calcium Binding Protein 39 Like
A scaffold protein in the LKB1-STRAD-MO25 complex, implicated in cell polarity and tumor suppression.
Gene Information Card
| Symbol | CAB39L |
|---|---|
| Full Name | Calcium Binding Protein 39 Like |
| Gene Type | Protein coding |
| Chromosomal Location | 13q14.2 |
| NCBI Gene ID | 81617 ncbi.nlm.nih.gov/gene/81617 |
| Ensembl ID | ENSG00000102572 |
| UniProt ID | Q9H9S0 |
| OMIM ID | 612175 |
| HGNC ID | 20293 |
| Aliases | MO25L, MO2CL1, bA152H21.1 |
Description
CAB39L (Calcium Binding Protein 39 Like) encodes a scaffold protein that forms a heterotrimeric complex with STK11 (LKB1) and STRAD (STE20-related kinase). This complex is essential for LKB1 kinase activity, which regulates cell polarity, energy metabolism, and tumor suppression. CAB39L is widely expressed and acts as a cofactor for LKB1-mediated phosphorylation of AMPK and other AMPK-related kinases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Loss of CAB39L expression or complex disruption impairs LKB1 tumor suppressor function, promoting cell proliferation and metastasis. | PMID: 19029980 |
| Peutz-Jeghers Syndrome (related) | CAB39L mutations are not directly causative but may modify LKB1 pathway activity in hamartomatous polyposis. | OMIM: 612175 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 10.2 | Medium |
| Testis | 15.8 | High |
| Lung | 7.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.2 | High expression in embryonic kidney cells |
| HeLa | 9.8 | Moderate expression in cervical cancer cells |
| A549 | 6.5 | Low expression in lung cancer cells |
| MCF7 | 11.1 | Medium expression in breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.511C>T (p.Arg171Trp) | Missense | <0.1% | Unknown functional effect; rare population variant |
| c.724G>A (p.Gly242Ser) | Missense | <0.1% | Predicted benign; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CAB39L.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • protein-containing complex (GO:0043234) | • nucleotide-activated protein kinase complex (GO:0031588) |
| • protein kinase activity, indirect (GO:0004672) |
Pathways
• LKB1 signaling pathway (Reactome: R-HSA-5628897)
• AMPK signaling (KEGG: hsa04152)
• mTOR signaling (Reactome: R-HSA-165159)
Protein Summary
CAB39L (MO25 beta) is a 341-amino acid scaffold protein that binds both LKB1 and STRAD, stabilizing the active LKB1-STRAD-MO25 complex. It does not possess intrinsic enzymatic activity but is critical for LKB1 kinase activation. The protein contains a conserved calcium-binding EF-hand domain, though calcium binding is not required for complex formation. CAB39L is ubiquitously expressed with highest levels in testis and brain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CAB39L Knockout HEK293 Cell Line | EDJ-KQ1181 | Human | 81617 | Details Get a Quote |
| CAB39L Knockout HCT 116 Cell Line | EDJ-KQ19105 | Human | 81617 | Details Get a Quote |
| CAB39L Knockout A-549 Cell Line | EDJ-KQ20460 | Human | 81617 | Details Get a Quote |
| CAB39L Knockout HeLa Cell Line | EDJ-KQ20461 | Human | 81617 | Details Get a Quote |
