C6orf58
Chromosome 6 Open Reading Frame 58
Gene Information Card
| Symbol | C6orf58 |
|---|---|
| Full Name | Chromosome 6 Open Reading Frame 58 |
| Gene Type | Protein-coding |
| Chromosomal Location | 6q22.31 |
| NCBI Gene ID | 387763 ncbi.nlm.nih.gov/gene/387763 |
| Ensembl ID | ENSG00000185010 |
| UniProt ID | Q6ZSR9 |
| OMIM ID | Not available |
| HGNC ID | HGNC:21032 |
| Aliases | FLJ45455, MGC16384 |
Description
C6orf58 is a protein-coding gene located on chromosome 6q22.31. The encoded protein has no well-characterized function, but expression data suggest potential roles in specific tissues. Limited information is available regarding its molecular function and disease associations.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No confirmed disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Salivary gland | 12.5 | Medium |
| Esophagus | 8.2 | Low |
| Stomach | 6.1 | Low |
| Thyroid | 4.3 | Low |
| Prostate | 3.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 2.1 | Low expression |
| HeLa | 1.5 | Low expression |
| HepG2 | 0.8 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Protein Summary
The C6orf58 protein (UniProt Q6ZSR9) is a 244-amino acid polypeptide with no known functional domains or motifs. Its biological role remains largely unknown, and no enzymatic or structural functions have been experimentally validated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| C6orf58 Knockout HEK293 Cell Line | EDJ-KQ12629 | Human | 352999 | Details Get a Quote |
| C6orf58 Knockout HeLa Cell Line | EDJ-KQ59850 | Human | 352999 | Details Get a Quote |
| C6orf58 Knockout A-549 Cell Line | EDJ-KQ68314 | Human | 352999 | Details Get a Quote |
| C6orf58 Knockout HCT 116 Cell Line | EDJ-KQ76688 | Human | 352999 | Details Get a Quote |
