C11orf65
Chromosome 11 Open Reading Frame 65
Gene Information Card
| Symbol | C11orf65 |
|---|---|
| Full Name | chromosome 11 open reading frame 65 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 160418 ncbi.nlm.nih.gov/gene/160418 |
| Ensembl ID | ENSG00000149021 |
| UniProt ID | Q8N7H5 |
| OMIM ID | 617270 |
| HGNC ID | 28673 |
| Aliases | FLJ10769, MGC14151 |
Description
C11orf65 is a protein-coding gene located on chromosome 11q13.1. The encoded protein has no well-characterized function but is predicted to be involved in cellular processes. Expression data suggest broad tissue distribution with low to moderate levels.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 3.8 | Low |
| Lung | 2.1 | Low |
| Liver | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.0 | Moderate expression |
| HeLa | 3.2 | Low expression |
| K562 | 2.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Protein Summary
The C11orf65 protein (UniProt Q8N7H5) is 244 amino acids long with no known domains or functional motifs. Its biological role remains uncharacterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| C11orf65 Knockout HEK293 Cell Line | EDJ-KQ12111 | Human | 160140 | Details Get a Quote |
| C11orf65 Knockout HCT 116 Cell Line | EDJ-KQ40793 | Human | 160140 | Details Get a Quote |
| C11orf65 Knockout HeLa Cell Line | EDJ-KQ58809 | Human | 160140 | Details Get a Quote |
| C11orf65 Knockout A-549 Cell Line | EDJ-KQ67293 | Human | 160140 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
