C10orf90
Chromosome 10 Open Reading Frame 90
Gene Information Card
| Symbol | C10orf90 |
|---|---|
| Full Name | chromosome 10 open reading frame 90 |
| Gene Type | protein-coding |
| Chromosomal Location | 10q26.13 |
| NCBI Gene ID | 118611 ncbi.nlm.nih.gov/gene/118611 |
| Ensembl ID | ENSG00000120071 |
| UniProt ID | Q96B26 |
| OMIM ID | 617733 |
| HGNC ID | 25871 |
| Aliases | FLJ10769, MGC131851 |
Description
C10orf90 is a protein-coding gene located on chromosome 10q26.13. It encodes a protein of unknown function, with no characterized domains or motifs. Expression data suggest it is widely expressed at low levels in various tissues. Limited evidence links C10orf90 to certain cancers, but its biological role remains poorly understood.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Potential tumor suppressor; reduced expression observed in some breast cancer cell lines | Low evidence: expression studies only |
| Lung cancer | Possible involvement in tumorigenesis; altered methylation reported | Low evidence: epigenetic studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 2.5 | Low |
| Brain | 1.8 | Low |
| Breast | 3.2 | Low |
| Colon | 2.1 | Low |
| Kidney | 1.5 | Low |
| Liver | 2.0 | Low |
| Lung | 2.8 | Low |
| Ovary | 1.9 | Low |
| Prostate | 2.3 | Low |
| Skin | 2.6 | Low |
| Testis | 3.0 | Low |
| Thyroid | 2.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.5 | Moderate expression in embryonic kidney cells |
| HeLa | 3.8 | Low expression in cervical cancer cells |
| MCF7 | 2.1 | Low expression in breast cancer cells |
| A549 | 3.0 | Low expression in lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | Unknown | Predicted to affect start codon; no functional data |
| c.100C>T | missense | Unknown | p.Arg34Cys; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Protein Summary
The C10orf90 protein (UniProt Q96B26) is 244 amino acids long with no characterized domains. Its function is unknown, and it has no known homologs with defined roles. No post-translational modifications or subcellular localization data are available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| C10orf90 Knockout HEK293 Cell Line | EDJ-KQ7626 | Human | 118611 | Details Get a Quote |
| C10orf90 Knockout HeLa Cell Line | EDJ-KQ58029 | Human | 118611 | Details Get a Quote |
| C10orf90 Knockout A-549 Cell Line | EDJ-KQ66517 | Human | 118611 | Details Get a Quote |
| C10orf90 Knockout HCT 116 Cell Line | EDJ-KQ74935 | Human | 118611 | Details Get a Quote |
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