BRMS1L
BRMS1 Like Transcriptional Repressor
Gene Information Card
| Symbol | BRMS1L |
|---|---|
| Full Name | BRMS1 Like Transcriptional Repressor |
| Gene Type | protein-coding |
| Chromosomal Location | 14q13.2 |
| NCBI Gene ID | 84312 ncbi.nlm.nih.gov/gene/84312 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q5VWQ0 |
| OMIM ID | 614692 |
| HGNC ID | 28338 |
| Aliases | BRMS1L, BRMS1-like, C14orf106, FLJ20533 |
Description
BRMS1L (BRMS1 Like Transcriptional Repressor) is a protein-coding gene located on chromosome 14q13.2. It encodes a component of the SIN3A histone deacetylase (HDAC) complex, involved in transcriptional repression. The protein shares homology with BRMS1 and is implicated in chromatin remodeling and gene silencing. BRMS1L is widely expressed in various tissues and may play a role in cancer metastasis suppression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Potential tumor suppressor; loss of BRMS1L expression may promote metastasis | Limited evidence from cell line studies; no direct OMIM or ClinVar entries |
| Melanoma | Reduced expression correlates with increased metastatic potential | Observational studies; not yet validated in large cohorts |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.8 | Low |
| Kidney | 5.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.0 | Moderate expression |
| MCF7 | 7.5 | Breast cancer cell line |
| A549 | 6.0 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.100C>T | nonsense | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations may lead to truncated protein and loss of repressor activity.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • transcriptional repressor activity | • chromatin binding |
| • histone deacetylase complex | • negative regulation of transcription by RNA polymerase II |
| • nucleus |
Pathways
• SIN3A/HDAC complex pathway
• Chromatin remodeling
Protein Summary
The BRMS1L protein is a 288-amino acid component of the SIN3A/HDAC transcriptional repression complex. It contains a coiled-coil domain and interacts with SIN3A to facilitate histone deacetylation and gene silencing. BRMS1L is localized to the nucleus and is thought to regulate genes involved in cell proliferation and metastasis. Its expression is reduced in some metastatic cancers, suggesting a tumor-suppressive role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| BRMS1L Knockout HEK293 Cell Line | EDJ-KQ9274 | Human | 84312 | Details Get a Quote |
| BRMS1L Knockout A-549 Cell Line | EDJ-KQ37106 | Human | 84312 | Details Get a Quote |
| BRMS1L Knockout HCT 116 Cell Line | EDJ-KQ37107 | Human | 84312 | Details Get a Quote |
| BRMS1L Knockout HeLa Cell Line | EDJ-KQ37108 | Human | 84312 | Details Get a Quote |
