BRMS1: Breast Cancer Metastasis Suppressor 1
A key regulator of metastasis suppression in multiple cancer types
Gene Information Card
| Symbol | BRMS1 |
|---|---|
| Full Name | Breast Cancer Metastasis Suppressor 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q13.2 |
| NCBI Gene ID | 25855 ncbi.nlm.nih.gov/gene/25855 |
| Ensembl ID | ENSG00000137709 |
| UniProt ID | Q9HCU9 |
| OMIM ID | 604759 |
| HGNC ID | 17262 |
| Aliases | DKFZp564A063, FLJ10521, MGC111024 |
Description
BRMS1 (Breast Cancer Metastasis Suppressor 1) is a protein-coding gene that encodes a member of the mSin3A histone deacetylase (HDAC) complex. The protein functions as a metastasis suppressor, inhibiting the spread of cancer cells from primary tumors to distant sites without affecting primary tumor growth. It is involved in transcriptional regulation, chromatin remodeling, and suppression of NF-kappaB signaling. BRMS1 is downregulated in several metastatic cancers, and its re-expression reduces metastatic potential in experimental models.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Loss of BRMS1 expression correlates with increased metastasis; re-expression suppresses metastasis via HDAC complex and NF-κB inhibition | PMID: 12676963, PMID: 18245496 |
| Melanoma | BRMS1 downregulation promotes metastasis; restoration reduces metastatic burden in xenograft models | PMID: 19029987 |
| Non-Small Cell Lung Cancer | Reduced BRMS1 expression associated with lymph node metastasis and poor prognosis | PMID: 21502317 |
| Ovarian Cancer | BRMS1 loss linked to peritoneal metastasis and shorter survival | PMID: 20629107 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 6.2 | Low |
| Lung | 5.8 | Low |
| Ovary | 4.5 | Low |
| Skin | 3.9 | Low |
| Brain | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 7.1 | Moderate expression |
| A549 (lung cancer) | 5.3 | Low expression |
| SK-MEL-28 (melanoma) | 4.0 | Low expression |
| HeLa (cervical cancer) | 6.5 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.256C>T (p.Arg86Trp) | Missense | Rare | Unknown functional impact |
| c.418G>A (p.Gly140Ser) | Missense | Rare | Unknown functional impact |
| c.1A>G (p.Met1Val) | Start loss | Rare | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Start loss mutations (e.g., p.Met1Val) and deletions are predicted to cause loss of BRMS1 protein function, reducing metastasis suppression.
Gain of Function (GOF)
No gain-of-function mutations have been reported for BRMS1.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for BRMS1.
View complete mutation data：
Gene Ontology (GO)
Pathways
• HDAC complex pathway (mSin3A complex)
• NF-kappaB signaling pathway (negative regulation)
Protein Summary
The BRMS1 protein is a 246-amino-acid component of the mSin3A histone deacetylase (HDAC) complex. It localizes to the nucleus and functions as a transcriptional corepressor. BRMS1 suppresses metastasis by modulating chromatin structure, repressing pro-metastatic genes, and inhibiting NF-κB activity. It does not affect primary tumor growth but specifically blocks the dissemination of cancer cells to distant organs. The protein contains two coiled-coil domains and a nuclear localization signal.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| BRMS1L Knockout HEK293 Cell Line | EDJ-KQ9274 | Human | 84312 | Details Get a Quote |
| BRMS1L Knockout A-549 Cell Line | EDJ-KQ37106 | Human | 84312 | Details Get a Quote |
| BRMS1L Knockout HCT 116 Cell Line | EDJ-KQ37107 | Human | 84312 | Details Get a Quote |
| BRMS1L Knockout HeLa Cell Line | EDJ-KQ37108 | Human | 84312 | Details Get a Quote |
| BRMS1 Knockout HEK293 Cell Line | EDJ-KQ51142 | Human | 25855 | Details Get a Quote |
| BRMS1 Knockout HeLa Cell Line | EDJ-KQ55834 | Human | 25855 | Details Get a Quote |
| BRMS1 Knockout A-549 Cell Line | EDJ-KQ64324 | Human | 25855 | Details Get a Quote |
| BRMS1 Knockout HCT 116 Cell Line | EDJ-KQ72777 | Human | 25855 | Details Get a Quote |
