ARMC12
Armadillo Repeat Containing 12
Gene Information Card
| Symbol | ARMC12 |
|---|---|
| Full Name | Armadillo Repeat Containing 12 |
| Gene Type | protein-coding |
| Chromosomal Location | 6q21 |
| NCBI Gene ID | 645973 ncbi.nlm.nih.gov/gene/645973 |
| Ensembl ID | ENSG00000188021 |
| UniProt ID | Q6P9B9 |
| OMIM ID | 618182 |
| HGNC ID | 26776 |
| Aliases | FLJ32743, MGC16384 |
Description
ARMC12 (Armadillo Repeat Containing 12) is a protein-coding gene located on chromosome 6q21. The encoded protein contains armadillo repeats, which are involved in protein-protein interactions. Its specific biological function is not fully characterized, but it may play a role in cellular signaling or structural organization.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.8 | Low |
| Adipose tissue | 3.2 | Low |
| Brain | 1.5 | Not detected |
| Liver | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 2.1 | Low expression |
| HeLa | 1.0 | Not detected |
| K562 | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Protein Summary
The ARMC12 protein (UniProt Q6P9B9) contains armadillo repeats, suggesting a role in mediating protein-protein interactions. Its exact molecular function and cellular localization remain largely unknown, with no established enzymatic or structural activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARMC12 Knockout HEK293 Cell Line | EDJ-KQ8833 | Human | 221481 | Details Get a Quote |
| ARMC12 Knockout HeLa Cell Line | EDJ-KQ59172 | Human | 221481 | Details Get a Quote |
| ARMC12 Knockout A-549 Cell Line | EDJ-KQ67645 | Human | 221481 | Details Get a Quote |
| ARMC12 Knockout HCT 116 Cell Line | EDJ-KQ76031 | Human | 221481 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
