ARMC10: Armadillo Repeat Containing 10
A mitochondrial-associated protein involved in cellular stress response and tumor suppression
Gene Information Card
| Symbol | ARMC10 |
|---|---|
| Full Name | Armadillo Repeat Containing 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 7q22.1 |
| NCBI Gene ID | 83787 ncbi.nlm.nih.gov/gene/83787 |
| Ensembl ID | ENSG00000106384 |
| UniProt ID | Q8N2F6 |
| OMIM ID | 616488 |
| HGNC ID | 24097 |
| Aliases | SVC, HSPC280, PNAS-137, dJ1156J10.1 |
Description
ARMC10 (Armadillo Repeat Containing 10) is a protein-coding gene located on chromosome 7q22.1. The encoded protein contains armadillo repeats and localizes to mitochondria, where it is involved in mitochondrial dynamics, cellular stress response, and regulation of apoptosis. ARMC10 has been implicated as a potential tumor suppressor in several cancers, including hepatocellular carcinoma and breast cancer. It interacts with proteins such as p53 and is downregulated in various malignancies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Downregulation of ARMC10 promotes cell proliferation and inhibits apoptosis via p53 pathway | PMID: 25944712 |
| Breast cancer | Reduced ARMC10 expression correlates with poor prognosis and increased metastasis | PMID: 27121396 |
| Colorectal cancer | ARMC10 methylation and silencing contribute to tumor progression | PMID: 28925394 |
| Gastric cancer | Loss of ARMC10 expression associated with advanced stage and lymph node metastasis | PMID: 29511378 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Heart | 9.8 | Medium |
| Kidney | 8.3 | Medium |
| Brain | 6.1 | Low |
| Lung | 5.4 | Low |
| Breast | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| MCF7 | 8.9 | Breast cancer cell line |
| HEK293 | 7.6 | Embryonic kidney cells |
| HeLa | 6.3 | Cervical cancer cells |
| A549 | 5.1 | Lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown functional effect |
| c.632A>G (p.Asn211Ser) | Missense | <0.01% | Unknown functional effect |
| c.1A>G (p.Met1Val) | Start loss | <0.01% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Start loss mutations (e.g., p.Met1Val) likely abolish protein translation, leading to loss of function.
Gain of Function (GOF)
No gain-of-function mutations reported in ARMC10.
Dominant Negative (DN)
No dominant-negative mutations reported in ARMC10.
View complete mutation data：
Gene Ontology (GO)
| • mitochondrion (GO:0005739) | • apoptotic process (GO:0006915) |
| • negative regulation of apoptotic process (GO:0043066) | • protein binding (GO:0005515) |
| • cytoplasm (GO:0005737) | • cytosol (GO:0005829) |
Pathways
• p53 signaling pathway (Reactome: R-HSA-3700989)
• Intrinsic pathway for apoptosis (Reactome: R-HSA-109606)
• Cellular responses to stress (Reactome: R-HSA-2262752)
Protein Summary
The ARMC10 protein (UniProt Q8N2F6) is a 337-amino acid armadillo repeat-containing protein that localizes to mitochondria. It contains five armadillo repeats that mediate protein-protein interactions. ARMC10 is involved in mitochondrial morphology regulation, apoptosis modulation, and cellular stress responses. It interacts with p53 and may act as a tumor suppressor by promoting apoptosis and inhibiting cell proliferation. The protein is widely expressed, with highest levels in liver, heart, and kidney.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARMC10 Knockout HEK293 Cell Line | EDJ-KQ9903 | Human | 83787 | Details Get a Quote |
| ARMC10 Knockout A-549 Cell Line | EDJ-KQ36792 | Human | 83787 | Details Get a Quote |
| ARMC10 Knockout HCT 116 Cell Line | EDJ-KQ36793 | Human | 83787 | Details Get a Quote |
| ARMC10 Knockout HeLa Cell Line | EDJ-KQ36794 | Human | 83787 | Details Get a Quote |
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