ARMC1: Armadillo Repeat Containing 1
A gene encoding a protein with armadillo repeats, involved in cellular signaling and potential roles in cancer and development.
Gene Information Card
| Symbol | ARMC1 |
|---|---|
| Full Name | Armadillo Repeat Containing 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 8q21.11 |
| NCBI Gene ID | 55156 ncbi.nlm.nih.gov/gene/55156 |
| Ensembl ID | ENSG00000104419 |
| UniProt ID | Q8N2F6 |
| OMIM ID | 615923 |
| HGNC ID | 23050 |
| Aliases | FLJ10769, MGC13170 |
Description
ARMC1 (Armadillo Repeat Containing 1) is a protein-coding gene located on chromosome 8q21.11. The encoded protein contains armadillo repeats, which are typically involved in protein-protein interactions and signal transduction. ARMC1 is ubiquitously expressed and may play roles in cell adhesion, Wnt signaling, and tumorigenesis. Mutations and altered expression have been reported in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered ARMC1 expression may affect Wnt/β-catenin signaling via armadillo repeat interactions | COSMIC, literature |
| Breast cancer | Overexpression observed; potential role in cell proliferation | COSMIC, literature |
| Lung cancer | Somatic mutations reported; functional impact under investigation | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Liver | 6.1 | Low |
| Kidney | 7.8 | Low |
| Heart | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.3 | Embryonic kidney; moderate expression |
| HeLa | 9.1 | Cervical cancer; moderate expression |
| A549 | 7.6 | Lung cancer; low expression |
| MCF7 | 11.2 | Breast cancer; moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | 0.01% | Unknown; likely benign |
| c.205G>A (p.Glu69Lys) | Missense | 0.005% | Unknown; predicted tolerated |
| c.412_413insA | Frameshift | <0.001% | Loss of function; truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift insertions or nonsense mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
No gain-of-function mutations have been reported for ARMC1.
Dominant Negative (DN)
No dominant-negative mutations have been described for ARMC1.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) | • signal transduction (GO:0007165) |
Pathways
• Wnt signaling pathway (Reactome: R-HSA-195721)
• Armadillo repeat family interactions (UniProt)
Protein Summary
The ARMC1 protein (UniProt Q8N2F6) contains armadillo repeats, which are helical domains that mediate protein-protein interactions. It is localized to the cytoplasm and nucleus and is involved in signal transduction, potentially modulating Wnt/β-catenin signaling. The protein is 668 amino acids long with a molecular weight of approximately 74 kDa.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARMC12 Knockout HEK293 Cell Line | EDJ-KQ8833 | Human | 221481 | Details Get a Quote |
| ARMC10 Knockout HEK293 Cell Line | EDJ-KQ9903 | Human | 83787 | Details Get a Quote |
| ARMC1 Knockout HEK293 Cell Line | EDJ-KQ12432 | Human | 55156 | Details Get a Quote |
| ARMC1 Knockout A-549 Cell Line | EDJ-KQ41354 | Human | 55156 | Details Get a Quote |
| ARMC1 Knockout HCT 116 Cell Line | EDJ-KQ41355 | Human | 55156 | Details Get a Quote |
| ARMC1 Knockout HeLa Cell Line | EDJ-KQ41356 | Human | 55156 | Details Get a Quote |
| ARMC10 Knockout A-549 Cell Line | EDJ-KQ36792 | Human | 83787 | Details Get a Quote |
| ARMC10 Knockout HCT 116 Cell Line | EDJ-KQ36793 | Human | 83787 | Details Get a Quote |
| ARMC10 Knockout HeLa Cell Line | EDJ-KQ36794 | Human | 83787 | Details Get a Quote |
| ARMC12 Knockout HeLa Cell Line | EDJ-KQ59172 | Human | 221481 | Details Get a Quote |
| ARMC12 Knockout A-549 Cell Line | EDJ-KQ67645 | Human | 221481 | Details Get a Quote |
| ARMC12 Knockout HCT 116 Cell Line | EDJ-KQ76031 | Human | 221481 | Details Get a Quote |
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