ARHGAP45
Rho GTPase Activating Protein 45
Gene Information Card
| Symbol | ARHGAP45 |
|---|---|
| Full Name | Rho GTPase Activating Protein 45 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 23511 ncbi.nlm.nih.gov/gene/23511 |
| Ensembl ID | ENSG00000105699 |
| UniProt ID | Q9H8H0 |
| OMIM ID | 617786 |
| HGNC ID | 25536 |
| Aliases | HMHA1, HA-1, ARHGAP45 |
Description
ARHGAP45 (Rho GTPase Activating Protein 45) encodes a member of the RhoGAP family of proteins that regulate Rho GTPases by accelerating GTP hydrolysis, thereby inactivating them. The protein is involved in cytoskeletal organization, cell migration, and immune cell function. It is also known as minor histocompatibility antigen HA-1 (HMHA1) and plays a role in graft-versus-host disease.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Graft-versus-host disease | HA-1 antigen mismatch between donor and recipient leads to T-cell recognition | PMID: 10545982 |
| Breast cancer | Altered expression may affect cell migration and invasion | PMID: 25691885 |
| Colorectal cancer | Potential role in tumor progression via Rho signaling | PMID: 29348626 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.9 | Medium |
| Lung | 5.1 | Low |
| Breast | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 15.3 | Leukemia cell line |
| HeLa | 7.2 | Cervical cancer cell line |
| MCF7 | 6.5 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T | missense | 0.01% | p.Thr34Met; unknown functional impact |
| c.452G>A | missense | 0.005% | p.Arg151Gln; predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • GTPase activator activity | • Rho GTPase binding |
| • cytoskeleton | • cell migration |
| • signal transduction |
Pathways
• Rho GTPase cycle
• Signaling by Rho family GTPases
Protein Summary
ARHGAP45 is a 730-amino acid protein containing a RhoGAP domain that inactivates RhoA, Rac1, and Cdc42. It localizes to the cytoplasm and membrane, regulating actin dynamics and cell adhesion. As HA-1, it is a minor histocompatibility antigen expressed on hematopoietic cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARHGAP45 Knockout HEK293 Cell Line | EDJ-KQ8052 | Human | 23526 | Details Get a Quote |
| ARHGAP45 Knockout A-549 Cell Line | EDJ-KQ33863 | Human | 23526 | Details Get a Quote |
| ARHGAP45 Knockout HCT 116 Cell Line | EDJ-KQ33864 | Human | 23526 | Details Get a Quote |
| ARHGAP45 Knockout HeLa Cell Line | EDJ-KQ33865 | Human | 23526 | Details Get a Quote |
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