APMAP (Adipocyte Plasma Membrane Associated Protein)
A transmembrane protein involved in adipocyte differentiation and potential metabolic disease links.
Gene Information Card
| Symbol | APMAP |
|---|---|
| Full Name | Adipocyte Plasma Membrane Associated Protein |
| Gene Type | protein-coding |
| Chromosomal Location | 20p11.23 |
| NCBI Gene ID | 57136 ncbi.nlm.nih.gov/gene/57136 |
| Ensembl ID | ENSG00000101452 |
| UniProt ID | Q9HDC9 |
| OMIM ID | 614711 |
| HGNC ID | 16276 |
| Aliases | C20orf3, UNQ303/PRO342 |
Description
APMAP (Adipocyte Plasma Membrane Associated Protein) encodes a transmembrane protein predominantly expressed in adipocytes. It is involved in adipocyte differentiation and may play a role in metabolic processes. The protein is localized to the plasma membrane and is associated with lipid metabolism and insulin sensitivity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | Altered APMAP expression may affect adipocyte differentiation and lipid storage, contributing to obesity. | NCBI Gene, UniProt |
| Type 2 Diabetes | APMAP variants may influence insulin resistance through effects on adipocyte function. | NCBI Gene, OMIM |
| Metabolic Syndrome | Dysregulation of APMAP in adipose tissue is linked to systemic metabolic disturbances. | UniProt, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 25.3 | High |
| Liver | 8.1 | Medium |
| Skeletal muscle | 5.2 | Low |
| Heart | 4.0 | Low |
| Kidney | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| 3T3-L1 (adipocyte) | 30.2 | High expression during differentiation |
| HepG2 (hepatocyte) | 6.8 | Moderate |
| HeLa (cervical) | 2.1 | Low |
| HEK293 (embryonic kidney) | 1.5 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Arg41Cys) | missense | <0.01% | Unknown functional effect |
| c.456G>A (p.Val152Met) | missense | <0.01% | Unknown functional effect |
| c.789_790insA | frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.789_790insA) are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No gain-of-function mutations have been reported for APMAP.
Dominant Negative (DN)
No dominant-negative mutations have been described for APMAP.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • protein binding (GO:0005515) |
| • lipid metabolic process (GO:0006629) | • cell differentiation (GO:0030154) |
| • fat cell differentiation (GO:0045444) |
Pathways
• Adipogenesis
• PPAR signaling pathway
Protein Summary
APMAP is a 416-amino acid transmembrane protein with a single pass domain. It is highly expressed in adipose tissue and is upregulated during adipocyte differentiation. The protein may function in lipid metabolism and insulin signaling, though its precise molecular role remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| APMAP Knockout HEK293 Cell Line | EDJ-KQ1957 | Human | 57136 | Details Get a Quote |
| APMAP Knockout A-549 Cell Line | EDJ-KQ21911 | Human | 57136 | Details Get a Quote |
| APMAP Knockout HCT 116 Cell Line | EDJ-KQ21912 | Human | 57136 | Details Get a Quote |
| APMAP Knockout HeLa Cell Line | EDJ-KQ21913 | Human | 57136 | Details Get a Quote |
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