ANO7
Anoctamin 7 (Transmembrane Protein 16G, TMEM16G)
Gene Information Card
| Symbol | ANO7 |
|---|---|
| Full Name | Anoctamin 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q37.3 |
| NCBI Gene ID | 100506658 ncbi.nlm.nih.gov/gene/100506658 |
| Ensembl ID | ENSG00000162949 |
| UniProt ID | Q6IWH7 |
| OMIM ID | 610096 |
| HGNC ID | 31832 |
| Aliases | TMEM16G, IPCA-5, PC-1, dJ366L4.1 |
Description
ANO7 (Anoctamin 7) encodes a member of the anoctamin family of calcium-activated chloride channels. The protein is predominantly expressed in prostate epithelium and is implicated in prostate cancer susceptibility and progression. ANO7 is also known as TMEM16G and IPCA-5 (Increased Prostate Cancer Antigen-5).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | ANO7 variants (e.g., rs77559646) are associated with increased risk; altered expression linked to tumor aggressiveness | GWAS and case-control studies (PMID: 29892012, 31019319) |
| Prostate hyperplasia | Expression changes observed in benign prostatic hyperplasia tissue | Expression profiling studies (PMID: 20676098) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 45.2 | High |
| Testis | 3.1 | Low |
| Kidney | 1.8 | Low |
| Lung | 0.9 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| LNCaP (prostate cancer) | 12.4 | Androgen-sensitive cell line |
| PC-3 (prostate cancer) | 8.7 | Androgen-independent cell line |
| DU145 (prostate cancer) | 6.2 | Brain metastasis-derived |
| HEK293 (embryonic kidney) | 0.3 | Low expression control |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs77559646 (G>A) | SNV | 0.05 (global) | Intronic variant; associated with prostate cancer risk |
| p.Arg375His | Missense | 0.001 | Rare variant; potential functional impact on channel activity |
| p.Gly400Ser | Missense | 0.002 | Rare variant; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
Not established for ANO7; some missense variants may reduce channel activity but evidence is limited.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005222 - intracellular calcium-activated chloride channel activity | • GO:0016021 - integral component of membrane |
| • GO:0005886 - plasma membrane | • GO:0006811 - ion transport |
| • GO:0070588 - calcium ion transmembrane transport |
Pathways
• Calcium signaling pathway (Reactome: R-HSA-4086400)
• Ion channel transport (Reactome: R-HSA-983712)
Protein Summary
ANO7 is a 933-amino acid transmembrane protein with eight transmembrane domains, functioning as a calcium-activated chloride channel. It is highly expressed in the prostate and localizes to the plasma membrane. The protein plays a role in ion homeostasis and may influence prostate cell proliferation and differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANO7 Knockout HEK293 Cell Line | EDJ-KQ10788 | Human | 50636 | Details Get a Quote |
| ANO7 Knockout A-549 Cell Line | EDJ-KQ38423 | Human | 50636 | Details Get a Quote |
| ANO7 Knockout HeLa Cell Line | EDJ-KQ38424 | Human | 50636 | Details Get a Quote |
| ANO7 Knockout HCT 116 Cell Line | EDJ-KQ73118 | Human | 50636 | Details Get a Quote |
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