ANGPTL6 (Angiopoietin Like 6)
A secreted glycoprotein involved in angiogenesis, energy metabolism, and hematopoietic stem cell regulation.
Gene Information Card
| Symbol | ANGPTL6 |
|---|---|
| Full Name | Angiopoietin Like 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 83854 ncbi.nlm.nih.gov/gene/83854 |
| Ensembl ID | ENSG00000130816 |
| UniProt ID | Q8NI99 |
| OMIM ID | 609117 |
| HGNC ID | 23139 |
| Aliases | AGF, angiopoietin-related growth factor, ARP5 |
Description
ANGPTL6 (Angiopoietin Like 6) encodes a secreted glycoprotein belonging to the angiopoietin-like family. It functions as a growth factor that stimulates angiogenesis, promotes hematopoietic stem cell expansion, and regulates energy metabolism by increasing insulin sensitivity and energy expenditure. The protein is primarily expressed in the liver and is involved in metabolic homeostasis and vascular development.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity and insulin resistance | ANGPTL6 overexpression improves insulin sensitivity and reduces adiposity; deficiency impairs glucose metabolism | Mouse models (Oike et al., 2005, Nat Med) |
| Hematopoietic disorders | Promotes ex vivo expansion of hematopoietic stem cells (HSCs) | In vitro and in vivo studies (Zhang et al., 2006, Blood) |
| Cancer (angiogenesis) | May promote tumor angiogenesis via endothelial cell activation | Expression studies in tumor tissues |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | High | High |
| Adipose tissue | Low | Low |
| Skeletal muscle | Low | Low |
| Heart | Low | Low |
| Kidney | Low | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 (liver cancer) | High | Hepatocellular carcinoma cell line |
| HUVEC (endothelial) | Low | Umbilical vein endothelial cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Cys) | Missense | Rare | Unknown functional effect |
| c.421G>A (p.Gly141Ser) | Missense | Rare | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in human disease.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • Angiogenesis (GO:0001525) | • Positive regulation of endothelial cell proliferation (GO:0001938) |
| • Positive regulation of insulin receptor signaling pathway (GO:0046628) | • Extracellular space (GO:0005615) |
| • Heparin binding (GO:0008201) |
Pathways
• Angiopoietin-like protein signaling
• Insulin signaling pathway (regulation)
• Hematopoietic stem cell regulation
Protein Summary
ANGPTL6 is a 470-amino-acid secreted glycoprotein with an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain. It binds to endothelial cells and promotes angiogenesis, enhances insulin sensitivity, and stimulates hematopoietic stem cell expansion. The protein is predominantly produced in the liver and circulates in the blood.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANGPTL6 Knockout HEK293 Cell Line | EDJ-KQ9908 | Human | 83854 | Details Get a Quote |
| ANGPTL6 Knockout HeLa Cell Line | EDJ-KQ57485 | Human | 83854 | Details Get a Quote |
| ANGPTL6 Knockout A-549 Cell Line | EDJ-KQ65987 | Human | 83854 | Details Get a Quote |
| ANGPTL6 Knockout HCT 116 Cell Line | EDJ-KQ74411 | Human | 83854 | Details Get a Quote |
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