ANGPTL2 (Angiopoietin Like 2)
A secreted glycoprotein involved in angiogenesis, inflammation, and metabolic regulation.
Gene Information Card
| Symbol | ANGPTL2 |
|---|---|
| Full Name | Angiopoietin Like 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q34.3 |
| NCBI Gene ID | 23452 ncbi.nlm.nih.gov/gene/23452 |
| Ensembl ID | ENSG00000136859 |
| UniProt ID | Q9UKU9 |
| OMIM ID | 605001 |
| HGNC ID | 490 |
| Aliases | ARP2, HARP |
Description
ANGPTL2 (Angiopoietin Like 2) is a member of the angiopoietin-like protein family. It encodes a secreted glycoprotein that functions in angiogenesis, inflammation, and lipid metabolism. The protein contains a coiled-coil domain and a fibrinogen-like domain, mediating interactions with integrins and other receptors. ANGPTL2 is implicated in various physiological and pathological processes, including metabolic disorders, cardiovascular disease, and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity and insulin resistance | ANGPTL2 promotes adipose tissue inflammation and impairs insulin signaling | PMID: 19252484 |
| Coronary artery disease | Elevated serum ANGPTL2 levels correlate with increased cardiovascular risk | PMID: 22158539 |
| Rheumatoid arthritis | ANGPTL2 is overexpressed in synovial tissue and promotes inflammatory cytokine production | PMID: 21159632 |
| Colorectal cancer | ANGPTL2 enhances tumor angiogenesis and metastasis via integrin signaling | PMID: 21502565 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Lung | 4.7 | Low |
| Skeletal muscle | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC | 15.2 | Endothelial cell line |
| HeLa | 8.9 | Cervical cancer cell line |
| HepG2 | 5.4 | Hepatocellular carcinoma cell line |
| A549 | 4.1 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | missense | 0.01% (gnomAD) | Unknown functional impact |
| c.457G>A (p.Gly153Ser) | missense | 0.005% (gnomAD) | Predicted benign |
| c.832C>T (p.Arg278Cys) | missense | 0.002% (gnomAD) | Predicted damaging (SIFT) |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ANGPTL2.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in ANGPTL2.
Dominant Negative (DN)
No dominant-negative mutations reported in ANGPTL2.
View complete mutation data：
Gene Ontology (GO)
| • angiogenesis | • positive regulation of cell migration |
| • positive regulation of inflammatory response | • integrin binding |
| • extracellular space |
Pathways
• Angiopoietin-like protein signaling
• Inflammatory response pathway
• Integrin signaling pathway
Protein Summary
ANGPTL2 is a 493-amino-acid secreted glycoprotein with a signal peptide, coiled-coil domain, and fibrinogen-like domain. It is primarily expressed in adipose tissue, heart, and vascular endothelium. The protein promotes angiogenesis, inflammation, and lipid metabolism by binding to integrins and activating downstream signaling pathways such as PI3K/Akt and NF-κB. Dysregulation of ANGPTL2 is linked to metabolic diseases, cardiovascular disorders, and cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANGPTL2 Knockout HEK293 Cell Line | EDJ-KQ7340 | Human | 23452 | Details Get a Quote |
| ANGPTL2 Knockout HeLa Cell Line | EDJ-KQ55743 | Human | 23452 | Details Get a Quote |
| ANGPTL2 Knockout A-549 Cell Line | EDJ-KQ64241 | Human | 23452 | Details Get a Quote |
| ANGPTL2 Knockout HCT 116 Cell Line | EDJ-KQ72686 | Human | 23452 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
