AMN1: Antagonist of Mitotic Exit Network 1
A gene encoding a protein involved in cell cycle regulation and linked to cancer and developmental disorders.
Gene Information Card
| Symbol | AMN1 |
|---|---|
| Full Name | Antagonist of Mitotic Exit Network 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p11.21 |
| NCBI Gene ID | 196394 ncbi.nlm.nih.gov/gene/196394 |
| Ensembl ID | ENSG00000111206 |
| UniProt ID | Q9H5J8 |
| OMIM ID | 618230 |
| HGNC ID | 25999 |
| Aliases | C12orf2, FLJ10324 |
Description
AMN1 encodes a protein that functions as an antagonist of the mitotic exit network, regulating cell cycle progression. It is involved in cytokinesis and may play a role in tumor suppression. The gene is located on chromosome 12p11.21 and is expressed in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of cell cycle control; AMN1 mutations may contribute to genomic instability | COSMIC; ClinVar |
| Developmental disorders | Potential role in cell division defects during embryogenesis | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Bone marrow | 10.5 | Medium |
| Lymph node | 8.3 | Low |
| Brain | 6.1 | Low |
| Liver | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.0 | Embryonic kidney cells |
| HeLa | 9.5 | Cervical cancer cells |
| K562 | 7.8 | Leukemia cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.1% | Unknown functional impact |
| c.250G>A (p.Gly84Ser) | Missense | <0.1% | Reported in COSMIC for colorectal cancer |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations may impair mitotic exit regulation, leading to aneuploidy.
Gain of Function (GOF)
No evidence of gain-of-function mutations in current databases.
Dominant Negative (DN)
Not documented.
View complete mutation data：
Gene Ontology (GO)
| • GO:0007049 - cell cycle | • GO:0051301 - cell division |
| • GO:0000281 - mitotic cytokinesis | • GO:0005515 - protein binding |
Pathways
• Mitotic exit network regulation
Protein Summary
The AMN1 protein is a 404-amino acid polypeptide that localizes to the cytoplasm and nucleus. It interacts with components of the mitotic exit network to ensure proper cytokinesis. Structural analysis suggests it contains coiled-coil domains involved in protein-protein interactions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| AMN1 Knockout HEK293 Cell Line | EDJ-KQ12341 | Human | 196394 | Details Get a Quote |
| AMN1 Knockout HeLa Cell Line | EDJ-KQ39934 | Human | 196394 | Details Get a Quote |
| AMN1 Knockout A-549 Cell Line | EDJ-KQ41192 | Human | 196394 | Details Get a Quote |
| AMN1 Knockout HCT 116 Cell Line | EDJ-KQ41193 | Human | 196394 | Details Get a Quote |
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