ALOX15B
Arachidonate 15-Lipoxygenase Type B
Gene Information Card
| Symbol | ALOX15B |
|---|---|
| Full Name | Arachidonate 15-Lipoxygenase Type B |
| Gene Type | Protein coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 247 ncbi.nlm.nih.gov/gene/247 |
| Ensembl ID | ENSG00000177575 |
| UniProt ID | O15296 |
| OMIM ID | 603697 |
| HGNC ID | 434 |
| Aliases | 15-LOX-2, 15-LOX-B |
Description
ALOX15B encodes a member of the lipoxygenase family that converts arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HPETE). The enzyme is involved in lipid peroxidation, inflammation, and cellular signaling. It is predominantly expressed in epithelial tissues and has been implicated in prostate cancer and other malignancies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate Cancer | Reduced expression of ALOX15B is associated with tumor progression; loss of 15-LOX-2 activity may promote carcinogenesis through altered eicosanoid signaling. | PMID: 11526490, PMID: 12619171 |
| Atherosclerosis | ALOX15B contributes to oxidative modification of low-density lipoproteins (LDL) in the arterial wall, promoting foam cell formation. | PMID: 10488063 |
| Inflammatory Bowel Disease | Altered ALOX15B expression in colonic mucosa may modulate inflammation via production of anti-inflammatory lipid mediators. | PMID: 16959936 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 12.5 | High |
| Skin | 8.3 | Medium |
| Lung | 6.1 | Medium |
| Colon | 4.7 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate cancer) | 15.2 | High expression |
| A549 (lung cancer) | 7.8 | Moderate expression |
| HaCaT (keratinocyte) | 9.4 | Moderate expression |
| HCT116 (colon cancer) | 3.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.143G>A (p.Arg48Gln) | Missense | <0.01% | Unknown functional impact |
| c.1066C>T (p.Arg356Trp) | Missense | <0.01% | Unknown functional impact |
| c.1750G>A (p.Gly584Ser) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • arachidonate 15-lipoxygenase activity | • iron ion binding |
| • oxidoreductase activity | • lipid metabolic process |
| • inflammatory response | • cellular response to oxidative stress |
Pathways
• Arachidonic acid metabolism (KEGG: hsa00590)
• Linoleic acid metabolism (KEGG: hsa00591)
• Biosynthesis of unsaturated fatty acids (KEGG: hsa01040)
Protein Summary
ALOX15B encodes a 676-amino acid protein (15-lipoxygenase-2) that contains a non-heme iron catalytic domain. The enzyme specifically oxygenates arachidonic acid at carbon 15 to produce 15(S)-HPETE, which is further metabolized to anti-inflammatory lipoxins and resolvins. The protein is localized to the cytoplasm and plasma membrane. Structural studies reveal a two-domain architecture: an N-terminal β-barrel domain and a C-terminal catalytic domain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ALOX15B Knockout HEK293 Cell Line | EDJ-KQ3377 | Human | 247 | Details Get a Quote |
| ALOX15B Knockout HeLa Cell Line | EDJ-KQ52600 | Human | 247 | Details Get a Quote |
| ALOX15B Knockout A-549 Cell Line | EDJ-KQ61077 | Human | 247 | Details Get a Quote |
| ALOX15B Knockout HCT 116 Cell Line | EDJ-KQ69559 | Human | 247 | Details Get a Quote |
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