AIMP2 (Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 2)
A scaffold protein of the multi-tRNA synthetase complex with roles in tumor suppression and neurodegeneration
Gene Information Card
| Symbol | AIMP2 |
|---|---|
| Full Name | Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 7p22.1 |
| NCBI Gene ID | 7965 ncbi.nlm.nih.gov/gene/7965 |
| Ensembl ID | ENSG00000106333 |
| UniProt ID | Q13155 |
| OMIM ID | 600859 |
| HGNC ID | 207 |
| Aliases | JTV1, p38, PRO0992 |
Description
AIMP2 (Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 2) encodes a scaffold protein that is a component of the multi-aminoacyl-tRNA synthetase complex. It plays critical roles in tRNA aminoacylation, translational control, and cellular signaling. AIMP2 also functions as a tumor suppressor by regulating p53 stability and apoptosis. Mutations and dysregulation of AIMP2 are implicated in various cancers and neurodegenerative disorders, including Parkinson disease.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Loss of AIMP2 expression leads to reduced p53 activation and increased cell proliferation | PMID: 12524540 |
| Parkinson disease | AIMP2 accumulation in dopaminergic neurons promotes alpha-synuclein aggregation and neurotoxicity | PMID: 20064376 |
| Colorectal cancer | AIMP2 downregulation correlates with poor prognosis and metastasis | PMID: 21804535 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Brain | 8.3 | Medium |
| Liver | 15.1 | High |
| Heart | 6.7 | Low |
| Kidney | 10.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.0 | Cervical cancer cell line |
| A549 | 11.5 | Lung adenocarcinoma cell line |
| SH-SY5Y | 9.8 | Neuroblastoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | Rare | Loss of start codon, reduced protein expression |
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Altered protein stability, associated with Parkinson disease |
Mutation functional classification
Loss of Function (LOF)
Reduced AIMP2 expression or loss-of-function mutations impair p53-mediated apoptosis and promote tumorigenesis.
Gain of Function (GOF)
Accumulation of AIMP2 in dopaminergic neurons contributes to Parkinson disease pathology.
Dominant Negative (DN)
Not reported for AIMP2.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005515 - protein binding | • GO:0003723 - RNA binding |
| • GO:0005852 - eukaryotic translation initiation factor 3 complex | • GO:0017101 - aminoacyl-tRNA synthetase multienzyme complex |
| • GO:0043065 - positive regulation of apoptotic process |
Pathways
• Aminoacyl-tRNA biosynthesis (KEGG: hsa00970)
• p53 signaling pathway (KEGG: hsa04115)
Protein Summary
AIMP2 is a 38 kDa scaffold protein that anchors multiple aminoacyl-tRNA synthetases within the multi-synthetase complex. It contains a GST-like domain and a leucine zipper motif. Beyond its role in translation, AIMP2 translocates to the nucleus upon stress to stabilize p53 and induce apoptosis. In neurons, AIMP2 accumulation impairs proteasomal function and promotes neurodegeneration.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| AIMP2 Knockout HEK293 Cell Line | EDJ-KQ6148 | Human | 7965 | Details Get a Quote |
| AIMP2 Knockout A-549 Cell Line | EDJ-KQ29945 | Human | 7965 | Details Get a Quote |
| AIMP2 Knockout HCT 116 Cell Line | EDJ-KQ29946 | Human | 7965 | Details Get a Quote |
| AIMP2 Knockout HeLa Cell Line | EDJ-KQ29947 | Human | 7965 | Details Get a Quote |
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