ADGRL4 (Adhesion G Protein-Coupled Receptor L4)
Also known as ELTD1; a potential biomarker in angiogenesis and cancer
Gene Information Card
| Symbol | ADGRL4 |
|---|---|
| Full Name | Adhesion G Protein-Coupled Receptor L4 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p31.1 |
| NCBI Gene ID | 64123 ncbi.nlm.nih.gov/gene/64123 |
| Ensembl ID | ENSG00000162618 |
| UniProt ID | Q9HAR2 |
| OMIM ID | 616419 |
| HGNC ID | 18787 |
| Aliases | ELTD1, ETL, GPR113 |
Description
ADGRL4 (adhesion G protein-coupled receptor L4), also known as ELTD1, is a member of the adhesion GPCR family. It is involved in angiogenesis, vascular development, and may play a role in tumor progression. The gene is located on chromosome 1p31.1 and encodes a 7-transmembrane receptor with a large extracellular domain containing EGF-like and hormone receptor motifs.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioblastoma | Overexpression of ADGRL4 promotes tumor angiogenesis and invasiveness | PMID: 25944712 |
| Colorectal cancer | Upregulation associated with poor prognosis and metastasis | PMID: 28411376 |
| Breast cancer | Elevated expression correlates with tumor grade and angiogenesis | PMID: 29351280 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.3 | Medium |
| Lung | 8.7 | Low |
| Kidney | 15.1 | Medium |
| Brain | 6.2 | Low |
| Placenta | 22.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC (endothelial) | 18.5 | High expression in endothelial cells |
| HEK293 | 3.2 | Low expression |
| U87MG (glioblastoma) | 14.8 | Overexpressed in glioblastoma cell lines |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A (p.Gly412Arg) | Missense | <0.01% (gnomAD) | Unknown functional impact |
| c.56C>T (p.Thr19Met) | Missense | <0.01% (gnomAD) | Likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ADGRL4.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway | • angiogenesis |
| • cell adhesion | • plasma membrane |
| • integral component of membrane |
Pathways
• GPCR signaling
• Adhesion GPCR pathway
Protein Summary
ADGRL4 is a 7-transmembrane adhesion GPCR with a large N-terminal extracellular domain containing EGF-like repeats and a hormone receptor domain. It is expressed predominantly in endothelial cells and is implicated in angiogenesis and tumor progression. The protein may mediate cell-cell and cell-matrix interactions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ADGRL4 Knockout HEK293 Cell Line | EDJ-KQ2833 | Human | 64123 | Details Get a Quote |
| ADGRL4 Knockout HeLa Cell Line | EDJ-KQ57033 | Human | 64123 | Details Get a Quote |
| ADGRL4 Knockout A-549 Cell Line | EDJ-KQ65539 | Human | 64123 | Details Get a Quote |
| ADGRL4 Knockout HCT 116 Cell Line | EDJ-KQ73974 | Human | 64123 | Details Get a Quote |
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