ADAMTS15
ADAM Metallopeptidase with Thrombospondin Type 1 Motif 15
Gene Information Card
| Symbol | ADAMTS15 |
|---|---|
| Full Name | ADAM metallopeptidase with thrombospondin type 1 motif 15 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q24.3 |
| NCBI Gene ID | 170689 ncbi.nlm.nih.gov/gene/170689 |
| Ensembl ID | ENSG00000166106 |
| UniProt ID | Q8TE58 |
| OMIM ID | 607510 |
| HGNC ID | 16300 |
| Aliases | ADAMTS15, ADAMTS-15, METH-8 |
Description
ADAMTS15 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of zinc-dependent metalloproteinases. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which functions in the degradation of proteoglycans such as aggrecan and versican. ADAMTS15 is involved in extracellular matrix remodeling, cell migration, and has been implicated in cancer progression and osteoarthritis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Osteoarthritis | ADAMTS15 contributes to aggrecan degradation in articular cartilage, leading to joint degeneration. | PMID: 19330029 |
| Colorectal cancer | ADAMTS15 expression is downregulated in colorectal tumors; loss of function may promote tumor invasion. | PMID: 21947005 |
| Breast cancer | ADAMTS15 acts as a tumor suppressor; reduced expression correlates with poor prognosis. | PMID: 25695637 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 2.3 | Low |
| Breast | 1.8 | Low |
| Colon | 3.1 | Medium |
| Kidney | 1.5 | Low |
| Liver | 0.9 | Not detected |
| Lung | 2.0 | Low |
| Ovary | 2.5 | Low |
| Prostate | 1.2 | Low |
| Skin | 1.6 | Low |
| Testis | 4.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 2.1 | Low expression |
| HT-29 (colorectal cancer) | 1.5 | Low expression |
| HEK 293 (embryonic kidney) | 3.8 | Medium expression |
| HepG2 (liver cancer) | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1276C>T (p.Arg426*) | Nonsense | <0.1% in COSMIC | Loss of function; truncation of catalytic domain |
| c.1672G>A (p.Gly558Arg) | Missense | 0.2% in COSMIC | Unknown; predicted damaging by SIFT |
| c.2149_2150insA (p.Thr717Asnfs*12) | Frameshift | <0.1% in COSMIC | Loss of function; premature stop |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Arg426*, p.Thr717Asnfs*12) result in truncated protein lacking catalytic activity.
Gain of Function (GOF)
No gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No dominant-negative mutations described in literature.
View complete mutation data：
Gene Ontology (GO)
Pathways
• ECM degradation (Reactome: R-HSA-1474228)
• Aggrecan degradation in osteoarthritis (KEGG: hsa05320)
Protein Summary
ADAMTS15 is a secreted metalloproteinase composed of a signal peptide, a prodomain, a catalytic domain with a zinc-binding motif, a disintegrin-like domain, a central thrombospondin type 1 repeat, a cysteine-rich domain, and a spacer region. The enzyme cleaves aggrecan at the Glu373-Ala374 bond and versican at the Glu441-Ala442 bond. Its activity is regulated by tissue inhibitors of metalloproteinases (TIMPs). ADAMTS15 is widely expressed in adult tissues, with highest levels in testis and colon. Reduced expression is observed in several cancers, suggesting a tumor-suppressive role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ADAMTS15 Knockout HEK293 Cell Line | EDJ-KQ11966 | Human | 170689 | Details Get a Quote |
| ADAMTS15 Knockout A-549 Cell Line | EDJ-KQ40517 | Human | 170689 | Details Get a Quote |
| ADAMTS15 Knockout HeLa Cell Line | EDJ-KQ40518 | Human | 170689 | Details Get a Quote |
| ADAMTS15 Knockout HCT 116 Cell Line | EDJ-KQ75827 | Human | 170689 | Details Get a Quote |
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