ACOXL (Acyl-CoA Oxidase Like)
Peroxisomal acyl-CoA oxidase-like protein gene
Gene Information Card
| Symbol | ACOXL |
|---|---|
| Full Name | Acyl-CoA Oxidase Like |
| Gene Type | protein-coding |
| Chromosomal Location | 2q13 |
| NCBI Gene ID | 55289 ncbi.nlm.nih.gov/gene/55289 |
| Ensembl ID | ENSG00000115977 |
| UniProt ID | Q9NUJ1 |
| OMIM ID | 614482 |
| HGNC ID | 26015 |
| Aliases | ACOX3L, PALCOX, PCOXL |
Description
ACOXL encodes a peroxisomal acyl-CoA oxidase-like protein involved in fatty acid beta-oxidation. It is primarily expressed in liver and kidney and may play a role in metabolic regulation and peroxisomal function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression linked to metabolic reprogramming | COSMIC, literature |
| Hepatocellular carcinoma | Downregulation associated with poor prognosis | NCBI Gene, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Low |
| Adipose tissue | 6.1 | Low |
| Heart | 2.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Liver cancer cell line |
| HEK293 | 3.1 | Embryonic kidney |
| MCF7 | 1.8 | Breast cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T | Missense | 0.01% | p.Thr34Ile, unknown significance |
| c.452G>A | Missense | 0.005% | p.Arg151Gln, uncertain |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • GO:0003995 - acyl-CoA oxidase activity | • GO:0005777 - peroxisome |
| • GO:0006635 - fatty acid beta-oxidation |
Pathways
• Peroxisomal beta-oxidation (Reactome: R-HSA-77289)
Protein Summary
ACOXL is a 660-amino acid peroxisomal protein with acyl-CoA oxidase activity. It catalyzes the first step of very long-chain fatty acid beta-oxidation in peroxisomes. Expression is highest in liver and kidney.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ACOXL Knockout HEK293 Cell Line | EDJ-KQ12261 | Human | 55289 | Details Get a Quote |
| ACOXL Knockout HCT 116 Cell Line | EDJ-KQ41058 | Human | 55289 | Details Get a Quote |
| ACOXL Knockout HeLa Cell Line | EDJ-KQ56573 | Human | 55289 | Details Get a Quote |
| ACOXL Knockout A-549 Cell Line | EDJ-KQ65069 | Human | 55289 | Details Get a Quote |
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