ACKR3 (Atypical Chemokine Receptor 3)
Atypical chemokine receptor involved in cell migration, angiogenesis, and cancer progression
Gene Information Card
| Symbol | ACKR3 |
|---|---|
| Full Name | Atypical Chemokine Receptor 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q37.3 |
| NCBI Gene ID | 57007 ncbi.nlm.nih.gov/gene/57007 |
| Ensembl ID | ENSG00000144476 |
| UniProt ID | P25106 |
| OMIM ID | 610376 |
| HGNC ID | 23692 |
| Aliases | CXCR7, RDC1, CMKOR1, GPR159 |
Description
ACKR3 (Atypical Chemokine Receptor 3), also known as CXCR7, is a G protein-coupled receptor that binds chemokines such as CXCL12 (SDF-1) and CXCL11. Unlike typical chemokine receptors, ACKR3 does not signal through G proteins but acts as a scavenger receptor, modulating chemokine gradients and regulating cell migration, adhesion, and survival. It is widely expressed in embryonic and adult tissues, including the brain, heart, kidney, and immune cells. ACKR3 is implicated in cancer progression, angiogenesis, and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (breast, lung, prostate, glioblastoma) | Overexpression promotes tumor growth, angiogenesis, and metastasis via CXCL12 scavenging and β-arrestin signaling | COSMIC, ClinVar, literature |
| Cardiovascular disease | Regulates endothelial cell migration and vascular remodeling | Literature, UniProt |
| Inflammatory disorders | Modulates chemokine availability and leukocyte trafficking | Literature, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Kidney | 15.7 | Medium |
| Lung | 6.2 | Low |
| Liver | 3.1 | Not detected |
| Spleen | 9.8 | Low |
| Placenta | 20.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 18.5 | High expression |
| HeLa | 12.3 | Medium expression |
| MCF7 | 22.1 | High expression |
| A549 | 14.7 | Medium expression |
| U87MG | 25.0 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | 0.01% (gnomAD) | Unknown functional impact |
| c.482G>A (p.Arg161Gln) | Missense | 0.005% (gnomAD) | Unknown functional impact |
| c.788A>G (p.Asn263Ser) | Missense | 0.02% (gnomAD) | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ACKR3.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in ACKR3.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in ACKR3.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • chemokine binding |
| • chemokine receptor activity | • cell surface receptor signaling pathway |
| • positive regulation of cell migration | • angiogenesis |
| • negative regulation of chemokine-mediated signaling pathway |
Pathways
• Chemokine signaling pathway
• CXCR7-mediated signaling
• β-arrestin signaling
• PI3K-Akt signaling pathway
Protein Summary
ACKR3 is a 362-amino acid atypical chemokine receptor with seven transmembrane domains. It lacks G protein coupling but recruits β-arrestins upon ligand binding, leading to receptor internalization and scavenging of chemokines. The protein is N-glycosylated and expressed on the cell surface and in endosomes. It plays a critical role in development, immune regulation, and cancer biology.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ACKR3 Knockout HEK293 Cell Line | EDJ-KQ2468 | Human | 57007 | Details Get a Quote |
| ACKR3 Knockout A-549 Cell Line | EDJ-KQ23021 | Human | 57007 | Details Get a Quote |
| ACKR3 Knockout HeLa Cell Line | EDJ-KQ23022 | Human | 57007 | Details Get a Quote |
| ACKR3 Knockout HCT 116 Cell Line | EDJ-KQ73734 | Human | 57007 | Details Get a Quote |
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