ABCF2: ATP Binding Cassette Subfamily F Member 2
A member of the ABC transporter family involved in translational regulation and cellular stress responses.
Gene Information Card
| Symbol | ABCF2 |
|---|---|
| Full Name | ATP Binding Cassette Subfamily F Member 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 7q36.1 |
| NCBI Gene ID | 10061 ncbi.nlm.nih.gov/gene/10061 |
| Ensembl ID | ENSG00000106344 |
| UniProt ID | Q9UG63 |
| OMIM ID | 612510 |
| HGNC ID | 71 |
| Aliases | ABC50, EST123147, HUSSY-18 |
Description
ABCF2 encodes a member of the ATP-binding cassette (ABC) transporter superfamily. Unlike classical ABC transporters, ABCF2 lacks transmembrane domains and is localized to the cytoplasm and nucleus. It functions as a translational regulator by interacting with eukaryotic initiation factor 2 (eIF2) and ribosomes, and is implicated in cellular stress responses, including the unfolded protein response (UPR).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | ABCF2 overexpression may promote tumor growth via enhanced translation of oncogenic mRNAs. | COSMIC, NCBI |
| Colorectal cancer | Upregulation observed; potential role in chemoresistance. | COSMIC, PubMed |
| Hepatocellular carcinoma | ABCF2 expression correlates with poor prognosis and metastasis. | PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 10.2 | Medium |
| Breast | 8.9 | Low |
| Colon | 7.3 | Low |
| Testis | 15.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 14.3 | Overexpressed relative to normal breast tissue |
| HepG2 (liver cancer) | 16.8 | High expression |
| HT-29 (colorectal cancer) | 11.0 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015G>A (p.Gly339Arg) | Missense | <0.1% | Unknown functional impact |
| c.1420C>T (p.Arg474Cys) | Missense | <0.1% | Reported in COSMIC; potential loss of function |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function role in translation regulation.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • ATP binding | • translation regulator activity |
| • ribosome binding | • cellular response to stress |
| • cytoplasm | • nucleus |
Pathways
• Unfolded protein response (UPR)
• Translation regulation by eIF2
Protein Summary
ABCF2 (ABC50) is a 623-amino acid protein with two ATP-binding domains but no transmembrane segments. It shuttles between cytoplasm and nucleus, binds ATP, and interacts with eIF2 and ribosomes to modulate translation initiation. Under stress conditions, ABCF2 is upregulated and may help cells adapt by altering protein synthesis. Its overexpression in several cancers suggests a role in tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ABCF2 Knockout HEK293 Cell Line | EDJ-KQ50926 | Human | 10061 | Details Get a Quote |
| ABCF2 Knockout HeLa Cell Line | EDJ-KQ55309 | Human | 10061 | Details Get a Quote |
| ABCF2 Knockout A-549 Cell Line | EDJ-KQ63792 | Human | 10061 | Details Get a Quote |
| ABCF2 Knockout HCT 116 Cell Line | EDJ-KQ72249 | Human | 10061 | Details Get a Quote |
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