IL6ST Knockout NCI-H1299 Cell Line
Cat.No.:
EDJ-KZ3
Species:
Human
Cell Name:
NCI-H1299
Gene:
IL6ST
Gene ID:
3572
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ3 |
|---|---|
| Product Name | IL6ST Knockout NCI-H1299 Cell Line |
| Cell Line | NCI-H1299 |
| Cellosaurus ID | CVCL_0060 |
| Cell Line Synonyms | H1299, H-1299, NCIH1299 |
| Gene | IL6ST |
| Gene Synonyms | CD130|CDW130|GP130|HIES4|HIES4A|HIES4B|IL-6RB|IMD94|STWS2|sGP130 |
| Summary |
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
|
| Associated Diseases | Non-Small Cell Lung Carcinoma |
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: NCI-H1299 | STR Info (Cell bank) Cell Line: NCI-H1299 | ||||
| Allele1 | Allele2 | Allele3 | Allele1 | Allele2 | Allele3 | |
| Amelogenin | X | X | ||||
| CSF1PO | 12 | 12 | ||||
| D5S818 | 11 | 11 | ||||
| D7S820 | 10 | 10 | ||||
| D13S317 | 12 | 12 | ||||
| D16S539 | 12 | 13 | 12 | 13 | ||
| TPOX | 8 | 8 | ||||
| vWA | 16 | 17 | 18 | 16 | 17 | 18 |
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Required Accessories
Cell Culture Optimization Series
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