SLC17A9: Solute Carrier Family 17 Member 9
Vesicular nucleotide transporter (VNUT) involved in purinergic signaling and ATP storage.
Gene Information Card
| Symbol | SLC17A9 |
|---|---|
| Full Name | Solute Carrier Family 17 Member 9 |
| Gene Type | Protein coding |
| Chromosomal Location | 20q13.33 |
| NCBI Gene ID | 63910 ncbi.nlm.nih.gov/gene/63910 |
| Ensembl ID | ENSG00000101204 |
| UniProt ID | Q9BYT1 |
| OMIM ID | 612107 |
| HGNC ID | 26099 |
| Aliases | VNUT, vesicular nucleotide transporter |
Description
SLC17A9 encodes the vesicular nucleotide transporter (VNUT), which mediates the uptake of ATP and other nucleotides into secretory vesicles. This transport is essential for purinergic signaling, where ATP is released as a neurotransmitter or signaling molecule. VNUT is a member of the SLC17 family of anion transporters and is expressed in neurons, endocrine cells, and immune cells.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gout and hyperuricemia | Altered ATP release and purine metabolism may contribute to urate accumulation. | OMIM 612107; ClinVar |
| Neuropathic pain | Dysregulation of ATP release via VNUT in sensory neurons implicated in pain signaling. | PubMed; NCBI Gene |
| Inflammatory bowel disease | Abnormal purinergic signaling in gut epithelium linked to SLC17A9 expression changes. | NCBI Gene; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Adrenal gland | 8.3 | Low |
| Salivary gland | 6.7 | Low |
| Testis | 5.1 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.2 | Neuronal model |
| HEK293 (embryonic kidney) | 3.4 | Low expression |
| HepG2 (hepatocellular carcinoma) | 1.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown; predicted damaging |
| c.457G>A (p.Gly153Ser) | Missense | <0.01% | Unknown; predicted benign |
| c.1120A>G (p.Thr374Ala) | Missense | <0.01% | Unknown; predicted tolerated |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • GO:0015293 – symporter activity | • GO:0015321 – sodium-dependent phosphate transmembrane transporter activity |
| • GO:0015322 – ATP transmembrane transporter activity | • GO:0015849 – organic acid transport |
| • GO:0030659 – cytoplasmic vesicle membrane | • GO:0042470 – melanosome |
| • GO:0046873 – metal ion transmembrane transporter activity |
Pathways
• Purinergic signaling (Reactome R-HSA-418594)
• Neurotransmitter release cycle (Reactome R-HSA-112310)
• SLC-mediated transmembrane transport (Reactome R-HSA-425407)
Protein Summary
The SLC17A9 protein (VNUT) is a multi-pass membrane protein localized to vesicular membranes. It transports ATP and other nucleotides from the cytosol into secretory vesicles, driven by a proton gradient. VNUT is critical for ATP-dependent signaling in neurons, neuroendocrine cells, and immune cells. Its structure includes 12 transmembrane domains and a conserved anion-binding motif.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC17A9 Knockout HEK293 Cell Line | EDJ-KQ12227 | Human | 63910 | Details Get a Quote |
| SLC17A9 Knockout HeLa Cell Line | EDJ-KQ18193 | Human | 63910 | Details Get a Quote |
| SLC17A9 Knockout HCT 116 Cell Line | EDJ-KQ40984 | Human | 63910 | Details Get a Quote |
| SLC17A9 Knockout A-549 Cell Line | EDJ-KQ65499 | Human | 63910 | Details Get a Quote |
| SLC17A9 Knockout Huh-7 Cell Line | EDC08601 | Human | 63910 | Details Get a Quote |
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