SQSTM1 Knockout BEAS-2B Cell Line
Cat.No.:
EDJ-KZ491
Species:
Human
Cell Name:
BEAS-2B
Gene:
SQSTM1
Gene ID:
8878
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ491 |
|---|---|
| Product Name | SQSTM1 Knockout BEAS-2B Cell Line |
| Cell Line | BEAS-2B |
| Cellosaurus ID | CVCL_0168 |
| Cell Line Synonyms | Beas-2B, BEAS 2B, BEAS2B, Beas2B, Bronchial Epithelium transformed with Ad12-SV40 2B |
| Gene | SQSTM1 |
| Gene Synonyms | A170|DMRV|EBIAP|FTDALS3|NADGP|OSIL|PDB3|ZIP3|p60|p62|p62B |
| Summary |
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
|
| Associated Diseases | Non-tumor |
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: BEAS-2B | STR Info (Cell bank) Cell Line: BEAS-2B | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| Amelogenin | X | Y | X | Y |
| D5S818 | 12 | 13 | 12 | 13 |
| D13S317 | 13 | 13 | ||
| D7S820 | 10 | 13 | 10 | 13 |
| D16S539 | 12 | 12 | ||
| vWA | 17 | 18 | 17 | 18 |
| TH01 | 7 | 9.3 | 7 | 9.3 |
| TPOX | 6 | 11 | 6 | 11 |
| CSF1PO | 9 | 12 | 9 | 12 |
| D19S433 | 13.2 | 15.2 | 13.2 | 15.2 |
| D21S11 | 28 | 30 | 28 | 30 |
| D18S51 | 18 | 19 | 18 | 19 |
| D6S1043 | 12 | 18 | ||
| D3S1358 | 15 | 17 | 15 | 17 |
| Penta D | 2.2 | 13 | 2.2 | 13 |
| D2S441 | 11 | 11.3 | 11 | 11.3 |
| D8S1179 | 13 | 15 | 13 | 15 |
| Penta E | 5 | 8 | 5 | 8 |
| D12S391 | 17 | 18 | 17 | 18 |
| D2S1338 | 22 | 23 | 22 | 23 |
| FGA | 20 | 24 | 20 | 24 |
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Related Publications
Long-term SiNPs exposure induced genetic instability and malignant transformation via SQSTM1/p62-mediated autophagy dysfunction in lungs.
IF=10.2
Materials today. Bio
This KO model may be useful for:
- Investigating the role of SQSTM1/p62 in autophagy dysfunction and its contribution to genetic instability
- Studying mechanisms of malignant transformation induced by environmental toxicants such as SiNPs in lung epithelial cells
- Evaluating the impact of SQSTM1 loss on DNA damage response and genomic integrity
- Screening compounds that modulate autophagy or p62-mediated signaling pathways in respiratory toxicology
- Modeling early events in lung carcinogenesis linked to chronic exposure and autophagy impairment
Required Accessories
Cell Culture Optimization Series
Related Products
CRISPR Knockout Kit
Flash CRISPR Knockout Kit（Universal Version）Flash CRISPR Knockout Kit（Universal Version）
Flash-Pro CRISPR KO Kit (For Organoids / Stem Cells)Flash-Pro CRISPR KO Kit (For Organoids / Stem Cells)
