G6PD (p.G131V) Point Mutation in K-562 Cell Line
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Cat.No.:
EDC03145
Species:
Human
Cell Name:
K-562
Gene:
G6PD
Gene ID:
2539
Size:
1×10⁶cells
The G6PD (p.G131V) Point Mutation in K562 Cell Line is based on the newly developed Bingo™ platform, which utilizes an optimized and upgraded version of the Prime Editing (PE) gene point mutation system-currently the most efficient and safest technology available. This platform enables precise and efficient gene point mutation, resulting in a highly active and stable cell line.
| Cat.No. | EDC03145 |
|---|---|
| Product Name | G6PD (p.G131V) Point Mutation in K-562 Cell Line |
| Cell Line | K-562 |
| Gene ID | |
| Cellosaurus ID | CVCL_U226 |
| Mutation Site | p.G131V |
| Cell Line Synonyms | K562, K.562, K 562, KO, GM05372, GM05372E |
| Summary |
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
| Associated Diseases | Chronic Myelogenous Leukemia |
| Passage Ratio | 1:3 |
| Complete Culture Medium | IMDM+10% FBS |
| Freezing Medium | 95% complete culture medium+5% DMSO |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: K-562 | STR Info (Cell bank) Cell Line: K-562 | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| Amelogenin | X | X | ||
| CSF1P0 | 9 | 10 | 9 | 10 |
| D2S1338 | 17 | 17 | ||
| D3S1358 | 16 | 16 | ||
| D5S818 | 11 | 12 | 11 | 12 |
| D7S820 | 9 | 11 | 9 | 11 |
| D8S1179 | 12 | 12 | ||
| D13S317 | 8 | 8 | ||
| D16S539 | 11 | 12 | 11 | 12 |
| D18S51 | 15 | 16 | 15 | 16 |
| D19S433 | 14 | 14.2 | 14 | 14.2 |
| D21S11 | 29 | 31 | 29 | 31 |
| FGA | 21 | 24 | 21 | 24 |
| Penta D | 9 | 13 | 9 | 13 |
| Penta E | 5 | 14 | 5 | 14 |
| TH01 | 9.3 | 9.3 | ||
| TPOX | 8 | 9 | 8 | 9 |
| vWA | 16 | 16 | ||
| D6S1043 | 11 | |||
| D12S391 | 23 | 23 | ||
| D2S441 | 10 | 14 | 10 | 14 |
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Required Accessories
Cell Culture Optimization Series
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