TEAD1 Gene: Transcriptional Enhancer Factor TEF-1
Key regulator of Hippo signaling pathway and developmental processes
Gene Information Card
| Symbol | TEAD1 |
|---|---|
| Full Name | TEA domain transcription factor 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.3 |
| NCBI Gene ID | 7003 ncbi.nlm.nih.gov/gene/7003 |
| Ensembl ID | ENSG00000187079 |
| UniProt ID | P28347 |
| OMIM ID | 189967 |
| HGNC ID | 11714 |
| Aliases | TEF-1, TCF13, TEA1 |
Description
TEAD1 (TEA domain transcription factor 1) encodes a transcription factor that binds to the MCAT element in muscle-specific genes and is a key downstream effector of the Hippo signaling pathway. It regulates cell proliferation, differentiation, and organ size by interacting with co-activators such as YAP1 and WWTR1 (TAZ). TEAD1 is essential for embryonic development, particularly in heart, muscle, and neural tube formation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Sveinsson chorioretinal atrophy | Loss-of-function mutations in TEAD1 lead to retinal degeneration | OMIM #108985 |
| Colorectal cancer | TEAD1 overexpression and YAP1 activation promote tumor growth | COSMIC |
| Hepatocellular carcinoma | TEAD1 amplification and Hippo pathway dysregulation | COSMIC |
| Cardiac hypertrophy | TEAD1 mediates hypertrophic gene expression via YAP1 | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 42.3 | High |
| Skeletal muscle | 38.1 | High |
| Liver | 15.7 | Medium |
| Lung | 12.4 | Medium |
| Brain | 8.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 35.2 | Embryonic kidney cells |
| HeLa | 28.6 | Cervical cancer cells |
| HepG2 | 22.1 | Hepatocellular carcinoma cells |
| A549 | 18.4 | Lung carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.497C>T (p.Thr166Ile) | Missense | Rare | Loss of DNA-binding activity |
| c.1042G>A (p.Gly348Arg) | Missense | Rare | Impaired YAP1 interaction |
| c.1234_1235del (p.Leu412fs) | Frameshift | Rare | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Mutations that disrupt DNA binding or co-activator interaction, leading to reduced transcriptional activity (e.g., p.Thr166Ile).
Gain of Function (GOF)
Amplification or overexpression of TEAD1, often with YAP1, promoting oncogenic transcription.
Dominant Negative (DN)
Not well documented; some missense variants may interfere with wild-type TEAD1 function.
View complete mutation data：
Gene Ontology (GO)
| • GO:0000978 | • GO:0000981 |
| • GO:0001227 | • GO:0001228 |
| • GO:0005515 | • GO:0005634 |
| • GO:0006357 | • GO:0008134 |
| • GO:0045944 |
Pathways
• Hippo signaling pathway (KEGG: hsa04390)
• Transcriptional regulation by YAP1 (Reactome: R-HSA-8939211)
Protein Summary
TEAD1 is a 426-amino acid transcription factor containing a conserved TEA/ATTS DNA-binding domain. It forms complexes with YAP1/TAZ to regulate gene expression involved in cell growth, apoptosis, and differentiation. The protein is predominantly nuclear and is widely expressed in adult tissues, with highest levels in heart and skeletal muscle.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TEAD1 Knockout HEK293 Cell Line | EDJ-KQ1395 | Human | 7003 | Details Get a Quote |
| TEAD1 Knockout A-549 Cell Line | EDJ-KQ20920 | Human | 7003 | Details Get a Quote |
| TEAD1 Knockout HCT 116 Cell Line | EDJ-KQ20921 | Human | 7003 | Details Get a Quote |
| TEAD1 Knockout HeLa Cell Line | EDJ-KQ20922 | Human | 7003 | Details Get a Quote |
| Tead1 Knockout CT26.WT Cell Line | EDJ-KZ501 | Mouse | 21676 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
