LATS2 Gene - Large Tumor Suppressor Kinase 2
A key regulator of the Hippo signaling pathway, involved in organ size control and tumor suppression.
Gene Information Card
| Symbol | LATS2 |
|---|---|
| Full Name | Large Tumor Suppressor Kinase 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 13q12.11 |
| NCBI Gene ID | 26524 ncbi.nlm.nih.gov/gene/26524 |
| Ensembl ID | ENSG00000150457 |
| UniProt ID | Q9NRM7 |
| OMIM ID | 604861 |
| HGNC ID | 6515 |
| Aliases | KPM, LATS, LATS-2, LATS2_HUMAN, WARTS |
Description
LATS2 (Large Tumor Suppressor Kinase 2) is a serine/threonine protein kinase that functions as a core component of the Hippo signaling pathway. It phosphorylates and inactivates YAP1 and WWTR1/TAZ transcriptional coactivators, thereby regulating cell proliferation, apoptosis, and organ size. LATS2 also plays a role in mitotic progression, centrosome duplication, and DNA damage response. Loss of LATS2 function is implicated in various cancers, including breast, lung, and prostate cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | LATS2 loss leads to YAP/TAZ nuclear translocation and increased proliferation | PMID: 21258369 |
| Non-Small Cell Lung Cancer | LATS2 downregulation promotes EMT and metastasis | PMID: 23541922 |
| Prostate Cancer | LATS2 inactivation via promoter methylation or mutation drives tumor growth | PMID: 22430205 |
| Mesothelioma | LATS2 deletion or mutation contributes to Hippo pathway disruption | PMID: 25691885 |
| Hepatocellular Carcinoma | LATS2 suppression enhances YAP activity and liver tumorigenesis | PMID: 20562852 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Heart | 8.3 | Medium |
| Lung | 6.1 | Low |
| Liver | 5.4 | Low |
| Breast | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.1 | Embryonic kidney cells |
| HeLa | 7.8 | Cervical cancer cells |
| MCF7 | 5.3 | Breast cancer cells |
| A549 | 4.9 | Lung cancer cells |
| HepG2 | 3.6 | Liver cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <1% | Truncation, loss of kinase domain |
| c.789_790insA (p.Glu264fs) | Frameshift | <1% | Loss of function |
| c.1567G>A (p.Glu523Lys) | Missense | <1% | Impaired kinase activity |
| c.2011C>T (p.Arg671Trp) | Missense | <1% | Reduced YAP phosphorylation |
Mutation functional classification
Loss of Function (LOF)
Most LATS2 mutations in cancer are loss-of-function, including nonsense, frameshift, and missense variants that impair kinase activity or protein stability.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in LATS2.
Dominant Negative (DN)
Some missense mutations (e.g., p.Glu523Lys) may act in a dominant-negative manner by disrupting dimerization or substrate binding.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004674 - protein serine/threonine kinase activity | • GO:0005515 - protein binding |
| • GO:0006468 - protein phosphorylation | • GO:0007049 - cell cycle |
| • GO:0008285 - negative regulation of cell proliferation | • GO:0035329 - hippo signaling |
| • GO:0043066 - negative regulation of apoptotic process | • GO:0051301 - cell division |
Pathways
• Hippo signaling pathway (KEGG: hsa04390)
• Regulation of actin cytoskeleton (KEGG: hsa04810)
• Signaling by Hippo (Reactome: R-HSA-2028269)
Protein Summary
LATS2 encodes a 1088-amino acid serine/threonine kinase with an N-terminal UBA domain, a central kinase domain, and a C-terminal regulatory region. It is activated by MST1/2-mediated phosphorylation and forms a complex with MOB1 to phosphorylate YAP1 and TAZ, leading to their cytoplasmic retention and degradation. LATS2 also localizes to centrosomes and mitotic spindles, where it regulates centrosome duplication and mitotic fidelity. The protein is widely expressed, with highest levels in testis and heart.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LATS2 Knockout HEK293 Cell Line | EDJ-KQ1084 | Human | 26524 | Details Get a Quote |
| LATS2 Knockout A-549 Cell Line | EDJ-KQ20234 | Human | 26524 | Details Get a Quote |
| LATS2 Knockout HCT 116 Cell Line | EDJ-KQ20235 | Human | 26524 | Details Get a Quote |
| LATS2 Knockout HeLa Cell Line | EDJ-KQ20236 | Human | 26524 | Details Get a Quote |
| Lats2 Knockout 4T1 Cell Line | EDJ-KZ324 | Mouse | 50523 | Details Get a Quote |
| LATS2 Knockout HAP1 Cell Line | EDC08125 | Human | 26524 | Details Get a Quote |
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