IFI35 Gene - Interferon-Induced Protein 35
A key regulator of innate immunity and antiviral response
Gene Information Card
| Symbol | IFI35 |
|---|---|
| Full Name | Interferon-Induced Protein 35 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q21.31 |
| NCBI Gene ID | 3430 ncbi.nlm.nih.gov/gene/3430 |
| Ensembl ID | ENSG00000168079 |
| UniProt ID | P80217 |
| OMIM ID | 600534 |
| HGNC ID | 5399 |
| Aliases | IFP35, IFI35A, IFI35B |
Description
IFI35 (Interferon-Induced Protein 35) encodes a 35 kDa protein that is induced by type I and type II interferons. The protein contains two leucine zipper domains and is involved in the regulation of innate immune responses, including antiviral signaling and modulation of NF-κB activity. It interacts with other interferon-induced proteins such as IFI44 and NMI, and may play a role in cellular stress responses and apoptosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Systemic lupus erythematosus | IFI35 overexpression linked to interferon signature and immune dysregulation | PMID: 25605274 |
| Viral infections (e.g., influenza, hepatitis C) | IFI35 modulates antiviral signaling pathways | PMID: 21880757 |
| Cancer (breast, colorectal) | Dysregulated IFI35 expression may affect tumor immune surveillance | PMID: 29431739 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 15.3 | Medium |
| Liver | 8.7 | Low |
| Whole blood | 6.2 | Low |
| Lymph node | 18.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.2 | Cervical cancer cell line |
| A549 | 11.8 | Lung carcinoma cell line |
| THP-1 | 22.5 | Monocytic leukemia cell line |
| HepG2 | 9.3 | Hepatocellular carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | 0.01% | p.Met1Val; potential loss of start codon |
| c.214C>T | Missense | 0.02% | p.Arg72Cys; may alter protein stability |
| c.487G>A | Missense | 0.005% | p.Gly163Ser; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants near the N-terminus may impair translation or protein folding.
Gain of Function (GOF)
Not well characterized; no clear gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects in current literature.
View complete mutation data：ClinVar: https://www.clinvar.com/gene/3430 COSMIC: https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=IFI35
Gene Ontology (GO)
| • GO:0003723 - RNA binding | • GO:0005515 - protein binding |
| • GO:0042802 - identical protein binding | • GO:0060337 - type I interferon signaling pathway |
| • GO:0045087 - innate immune response | • GO:0005737 - cytoplasm |
Pathways
• Interferon alpha/beta signaling (Reactome: R-HSA-909733)
• Interferon gamma signaling (Reactome: R-HSA-877300)
• Innate Immune System (Reactome: R-HSA-168249)
Protein Summary
The IFI35 protein (UniProt P80217) is a 286-amino acid interferon-induced protein with two leucine zipper domains. It localizes to the cytoplasm and can form homodimers or heterodimers with NMI. It participates in antiviral responses by modulating transcription factors such as IRF1 and NF-κB. The protein is also implicated in the regulation of cell proliferation and apoptosis.
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFI35 Knockout HEK293 Cell Line | EDJ-KQ13799 | Human | 3430 | Details Get a Quote |
| IFI35 Knockout A-549 Cell Line | EDJ-KQ43601 | Human | 3430 | Details Get a Quote |
| IFI35 Knockout HCT 116 Cell Line | EDJ-KQ43602 | Human | 3430 | Details Get a Quote |
| IFI35 Knockout HeLa Cell Line | EDJ-KQ43603 | Human | 3430 | Details Get a Quote |
| IFI35 Knockout THP-1 Cell Line | EDJ-KZ29 | Human | 3430 | Details Get a Quote |
| Ifi35 Knockout 4T1 Cell Line | EDJ-KZ289 | Mouse | 70110 | Details Get a Quote |
Displaying Records 1 To 6 Of 6 Records
