ADIPOR2
Adiponectin Receptor 2
Gene Information Card
| Symbol | ADIPOR2 |
|---|---|
| Full Name | Adiponectin Receptor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.31 |
| NCBI Gene ID | 79602 ncbi.nlm.nih.gov/gene/79602 |
| Ensembl ID | ENSG00000106819 |
| UniProt ID | Q86V24 |
| OMIM ID | 607946 |
| HGNC ID | 24040 |
| Aliases | PAQR2, ACDCR2, FLJ21432 |
Description
ADIPOR2 (Adiponectin Receptor 2) is a protein-coding gene that encodes a receptor for adiponectin, a hormone secreted by adipose tissue involved in glucose and lipid metabolism. The receptor mediates increased AMPK and PPAR-alpha ligand activities, leading to fatty acid oxidation and glucose uptake. ADIPOR2 is widely expressed and plays a role in insulin sensitivity, inflammation, and energy homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Type 2 Diabetes | Reduced ADIPOR2 expression impairs adiponectin signaling, decreasing insulin sensitivity and glucose uptake. | ClinVar, NCBI |
| Obesity | Altered ADIPOR2 levels correlate with adiposity and metabolic dysfunction. | NCBI, OMIM |
| Metabolic Syndrome | Dysregulation of ADIPOR2 contributes to insulin resistance, dyslipidemia, and hypertension. | NCBI |
| Non-alcoholic Fatty Liver Disease (NAFLD) | Reduced hepatic ADIPOR2 expression is associated with steatosis and inflammation. | NCBI |
| Cardiovascular Disease | Impaired adiponectin signaling via ADIPOR2 may promote atherosclerosis. | NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skeletal Muscle | 12.5 | Medium |
| Liver | 8.3 | Medium |
| Adipose Tissue | 10.1 | Medium |
| Heart | 7.9 | Medium |
| Kidney | 6.4 | Low |
| Pancreas | 5.2 | Low |
| Brain | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 9.8 | Hepatocellular carcinoma cell line |
| C2C12 | 11.2 | Mouse myoblast cell line |
| 3T3-L1 | 10.5 | Adipocyte precursor cell line |
| MCF7 | 4.3 | Breast cancer cell line |
| HEK293 | 6.7 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100G>A (p.Gly34Arg) | Missense | <0.01% | Unknown functional impact |
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | May alter receptor activity |
| c.712A>G (p.Ile238Val) | Missense | <0.01% | Likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：ClinVar: https://www.clinvar.com/gene/79602 COSMIC: https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=ADIPOR2
Gene Ontology (GO)
| • adiponectin receptor activity | • G protein-coupled receptor activity |
| • signal transduction | • positive regulation of fatty acid oxidation |
| • positive regulation of glucose import | • AMPK activation |
| • cellular response to hormone stimulus |
Pathways
• Adiponectin signaling pathway
• AMPK signaling pathway
• PPAR signaling pathway
• Insulin signaling pathway
Protein Summary
Adiponectin receptor 2 (ADIPOR2) is a 375-amino acid transmembrane protein with seven membrane-spanning domains, structurally distinct from classical GPCRs. It binds adiponectin and mediates downstream activation of AMPK and PPAR-alpha, promoting fatty acid oxidation, glucose uptake, and anti-inflammatory effects. ADIPOR2 is ubiquitously expressed, with highest levels in skeletal muscle, liver, and adipose tissue.
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ADIPOR2 Knockout HEK293 Cell Line | EDJ-KQ1861 | Human | 79602 | Details Get a Quote |
| ADIPOR2 Knockout A-549 Cell Line | EDJ-KQ21727 | Human | 79602 | Details Get a Quote |
| ADIPOR2 Knockout HCT 116 Cell Line | EDJ-KQ21728 | Human | 79602 | Details Get a Quote |
| ADIPOR2 Knockout HeLa Cell Line | EDJ-KQ21729 | Human | 79602 | Details Get a Quote |
| Adipor2 Knockout CHO-K1 Cell Line | EDJ-KZ529 | Hamster | 79602 | Details Get a Quote |
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