TP53TG1 (TP53 Target Gene 1)
A p53-regulated long non-coding RNA involved in DNA damage response and tumor suppression
Gene Information Card
| Symbol | TP53TG1 |
|---|---|
| Full Name | TP53 Target Gene 1 |
| Gene Type | Long non-coding RNA (lncRNA) |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 11257 ncbi.nlm.nih.gov/gene/11257 |
| Ensembl ID | ENSG00000214753 |
| UniProt ID | Not applicable (non-coding RNA) |
| OMIM ID | Not available |
| HGNC ID | 11998 |
| Aliases | LINC00679, NCRNA00079, p53-induced gene 1 |
Description
TP53TG1 (TP53 Target Gene 1) is a long non-coding RNA (lncRNA) that is transcriptionally activated by the tumor suppressor p53 in response to DNA damage. It plays a role in regulating apoptosis, cell cycle arrest, and DNA repair pathways. TP53TG1 is frequently downregulated in various cancers, suggesting a tumor-suppressive function. Its expression is associated with poor prognosis in some malignancies, and it may act as a competing endogenous RNA (ceRNA) to modulate microRNA activity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Downregulation of TP53TG1 leads to increased cell proliferation and invasion via miRNA sponging | PMID: 28431213 |
| Colorectal cancer | Reduced TP53TG1 expression correlates with advanced tumor stage and metastasis | PMID: 29348672 |
| Gastric cancer | TP53TG1 silencing promotes epithelial-mesenchymal transition (EMT) | PMID: 30131733 |
| Hepatocellular carcinoma | TP53TG1 acts as a tumor suppressor by regulating p53 signaling | PMID: 31065024 |
| Lung cancer | Low TP53TG1 levels associated with poor survival and chemoresistance | PMID: 31525678 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 0.5 | Low |
| Breast | 1.2 | Low |
| Colon | 2.8 | Medium |
| Liver | 3.1 | Medium |
| Lung | 1.5 | Low |
| Stomach | 2.0 | Medium |
| Testis | 4.5 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF-7 (breast cancer) | 2.3 | Moderate expression |
| HCT-116 (colorectal cancer) | 3.8 | High expression |
| HepG2 (liver cancer) | 4.1 | High expression |
| A549 (lung cancer) | 1.9 | Low expression |
| K562 (leukemia) | 0.8 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1-100A>G | SNV | <0.1% | Unknown; likely non-coding regulatory variant |
| c.200+1G>T | Splice site | <0.1% | May affect transcript stability |
| c.350C>T | SNV | <0.1% | No functional data available |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; downregulation of TP53TG1 in tumors suggests loss of tumor-suppressive function.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not applicable (non-coding RNA).
View complete mutation data：
Gene Ontology (GO)
| • Not applicable (non-coding RNA) |
Pathways
• p53 signaling pathway
• DNA damage response
• Apoptosis
Protein Summary
TP53TG1 does not encode a protein; it functions as a long non-coding RNA that regulates gene expression through interactions with microRNAs and chromatin-modifying complexes.
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