TMEM205: Transmembrane Protein 205
A multi-pass membrane protein implicated in drug resistance and cancer biology
Gene Information Card
| Symbol | TMEM205 |
|---|---|
| Full Name | Transmembrane Protein 205 |
| Gene Type | Protein coding |
| Chromosomal Location | 19p13.12 |
| NCBI Gene ID | 374882 ncbi.nlm.nih.gov/gene/374882 |
| Ensembl ID | ENSG00000188010 |
| UniProt ID | Q6UW68 |
| OMIM ID | 616447 |
| HGNC ID | 28032 |
| Aliases | MGC13170, PRO399 |
Description
TMEM205 (Transmembrane Protein 205) is a protein-coding gene located on chromosome 19p13.12. It encodes a multi-pass membrane protein of unknown function but is implicated in cellular resistance to platinum-based chemotherapeutic agents, particularly cisplatin. Overexpression of TMEM205 has been observed in cisplatin-resistant cancer cell lines and in certain tumor tissues, suggesting a role in acquired chemoresistance. The protein is localized to the plasma membrane and intracellular membranes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Ovarian cancer | Overexpression associated with cisplatin resistance in cell line models | PMID: 20053767 |
| Pancreatic cancer | Upregulation in resistant cell lines; potential biomarker for chemoresistance | PMID: 23149930 |
| Breast cancer | Differential expression in tumor vs normal tissue; functional role unclear | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 9.8 | Medium |
| Kidney | 7.2 | Medium |
| Pancreas | 5.1 | Low |
| Ovary | 4.3 | Low |
| Breast | 3.6 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 12.5 | Cervical cancer cell line |
| A549 | 8.9 | Lung cancer cell line |
| MCF7 | 6.2 | Breast cancer cell line |
| PANC-1 | 5.8 | Pancreatic cancer cell line |
| SKOV3 | 4.1 | Ovarian cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown; predicted benign |
| c.100C>T | Missense | <0.01% | Unknown; predicted tolerated |
| c.200G>A | Missense | <0.01% | Unknown; predicted possibly damaging |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
Overexpression in resistant cell lines suggests potential gain-of-function in chemoresistance.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • GO:0016021 - integral component of membrane | • GO:0005886 - plasma membrane |
| • GO:0042493 - response to drug |
Pathways
• Platinum drug resistance pathway (Reactome: R-HSA-9755511)
Protein Summary
TMEM205 is a 189-amino-acid multi-pass transmembrane protein with no known enzymatic activity. It is predicted to contain four transmembrane helices. The protein is localized to the plasma membrane and may function in drug transport or membrane signaling. Its overexpression in cisplatin-resistant cancer cells suggests a role in modulating cellular response to platinum-based chemotherapy.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM205 Knockout HEK293 Cell Line | EDJ-KQ15812 | Human | 374882 | Details Get a Quote |
| TMEM205 Knockout A-549 Cell Line | EDJ-KQ49025 | Human | 374882 | Details Get a Quote |
| TMEM205 Knockout HCT 116 Cell Line | EDJ-KQ49026 | Human | 374882 | Details Get a Quote |
| TMEM205 Knockout HeLa Cell Line | EDC90503 | Human | 374882 | Details Get a Quote |
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