ANKRD37
Ankyrin Repeat Domain 37
Gene Information Card
| Symbol | ANKRD37 |
|---|---|
| Full Name | Ankyrin Repeat Domain 37 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q35.1 |
| NCBI Gene ID | 353322 ncbi.nlm.nih.gov/gene/353322 |
| Ensembl ID | ENSG00000164171 |
| UniProt ID | Q9NVP2 |
| OMIM ID | 617607 |
| HGNC ID | 26710 |
| Aliases | Lrp2bp, MGC13170 |
Description
ANKRD37 encodes a protein containing ankyrin repeats, which are involved in protein-protein interactions. The gene is transcriptionally regulated by p53 and hypoxia-inducible factors, playing a role in cellular response to hypoxia and DNA damage. It is implicated in tumor suppression and metabolic adaptation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Downregulated in tumors; potential tumor suppressor via p53 pathway | NCBI Gene, COSMIC |
| Breast cancer | Altered expression linked to hypoxia response | NCBI Gene, COSMIC |
| Colorectal cancer | Methylation-associated silencing | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 2.3 | Low |
| Kidney | 1.8 | Low |
| Heart | 1.5 | Low |
| Brain | 1.2 | Low |
| Lung | 1.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 3.1 | Hepatocellular carcinoma cell line |
| MCF7 | 2.5 | Breast cancer cell line |
| HEK293 | 1.9 | Embryonic kidney cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | 0.01% | Unknown functional impact |
| c.100C>T | Nonsense | 0.005% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations may lead to truncated protein and loss of function.
Gain of Function (GOF)
No evidence of gain-of-function mutations.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • ankyrin repeat binding |
| • cellular response to hypoxia | • negative regulation of cell proliferation |
Pathways
• p53 signaling pathway
• Hypoxia-inducible factor pathway
Protein Summary
The ANKRD37 protein contains ankyrin repeats that mediate interactions with other proteins. It is induced under hypoxic conditions and by p53, suggesting a role in stress response and tumor suppression. Subcellular localization is predominantly nuclear and cytoplasmic.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANKRD37 Knockout HEK293 Cell Line | EDJ-KQ12368 | Human | 353322 | Details Get a Quote |
| ANKRD37 Knockout A-549 Cell Line | EDJ-KQ41222 | Human | 353322 | Details Get a Quote |
| ANKRD37 Knockout HCT 116 Cell Line | EDJ-KQ41223 | Human | 353322 | Details Get a Quote |
| ANKRD37 Knockout HeLa Cell Line | EDJ-KQ41224 | Human | 353322 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
