AJM1: A Key Component of the C. elegans Apical Junctional Complex
Essential for embryonic morphogenesis and epithelial barrier function in Caenorhabditis elegans
Gene Information Card
| Symbol | AJM1 |
|---|---|
| Full Name | Apical Junction Molecule 1 |
| Gene Type | protein-coding |
| Chromosomal Location | Chromosome I (C. elegans) |
| NCBI Gene ID | 175591 ncbi.nlm.nih.gov/gene/175591 |
| Ensembl ID | WBGene00000111 |
| UniProt ID | Q9U2M1 |
| OMIM ID | - |
| HGNC ID | - |
| Aliases | apj-1, K08D8.5 |
Description
AJM1 (Apical Junction Molecule 1) is a gene in Caenorhabditis elegans that encodes a coiled-coil protein localized to the apical junctional complex. It is required for the integrity of epithelial cell-cell junctions during embryonic morphogenesis and maintenance of the epithelial barrier. AJM1 interacts with other junctional components such as DLG-1 and is essential for proper embryonic elongation and organogenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No human disease association | AJM1 is not conserved in humans; no direct disease link established. | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Whole worm (C. elegans) | Not applicable (nTPM not defined for C. elegans) | High expression in embryos and adults |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| C. elegans embryonic cells | Not applicable | Expressed in hypodermal and intestinal cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| ajm1(ok160) | Deletion | Homozygous lethal | Loss of apical junction integrity, embryonic arrest |
Mutation functional classification
Loss of Function (LOF)
Loss of AJM1 disrupts apical junction formation, leading to embryonic lethality due to failed morphogenesis.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005911 - cell-cell junction | • GO:0005913 - adherens junction |
| • GO:0007049 - cell cycle | • GO:0009792 - embryonic development ending in birth or egg hatching |
| • GO:0016328 - lateral plasma membrane | • GO:0030054 - cell junction |
| • GO:0045216 - cell-cell junction organization |
Pathways
• Apical junction complex assembly (C. elegans)
Protein Summary
AJM1 is a 1,048-amino acid coiled-coil protein that localizes to the apical junctional complex in C. elegans epithelial cells. It does not contain transmembrane domains but associates with the junction via interactions with DLG-1 and other scaffolding proteins. AJM1 is essential for maintaining the structural integrity of the epithelial barrier and for proper embryonic elongation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| AJM1 Knockout HEK293 Cell Line | EDJ-KQ12318 | Human | 389813 | Details Get a Quote |
| AJM1 Knockout A-549 Cell Line | EDJ-KQ41154 | Human | 389813 | Details Get a Quote |
| AJM1 Knockout HCT 116 Cell Line | EDJ-KQ41155 | Human | 389813 | Details Get a Quote |
| AJM1 Knockout HeLa Cell Line | EDJ-KQ41156 | Human | 389813 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
