AIG1: Androgen-Induced Gene 1
AIG1 is a protein-coding gene associated with androgen response and potential roles in cancer and cellular stress.
Gene Information Card
| Symbol | AIG1 |
|---|---|
| Full Name | Androgen-Induced 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 6q24.3 |
| NCBI Gene ID | 51390 ncbi.nlm.nih.gov/gene/51390 |
| Ensembl ID | ENSG00000146416 |
| UniProt ID | Q9Y4K1 |
| OMIM ID | 608514 |
| HGNC ID | HGNC:24068 |
| Aliases | dJ402H5.2, FLJ10305, MGC138290 |
Description
AIG1 (Androgen-Induced 1) is a protein-coding gene located on chromosome 6q24.3. The encoded protein is induced by androgens and may play a role in cellular stress responses and cancer progression. Expression data suggest involvement in prostate and other hormone-sensitive tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate Cancer | Androgen-induced expression may promote tumor growth | NCBI Gene, PubMed |
| Breast Cancer | Potential role in hormone-responsive tumors | NCBI Gene, PubMed |
| Androgen Insensitivity Syndrome | Altered androgen signaling pathway | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 12.5 | Medium |
| Testis | 8.3 | Low |
| Breast | 6.1 | Low |
| Liver | 4.2 | Low |
| Kidney | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| LNCaP (prostate cancer) | 15.2 | Androgen-responsive cell line |
| MCF-7 (breast cancer) | 7.8 | Hormone receptor positive |
| HEK293 (embryonic kidney) | 5.1 | Baseline expression |
| HeLa (cervical cancer) | 4.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.347C>T | Missense | 0.01% | p.Thr116Ile, unknown significance |
| c.512A>G | Missense | 0.005% | p.Asn171Ser, uncertain |
| c.789delC | Frameshift | 0.001% | Loss of function, rare |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.789delC) likely result in truncated protein and loss of function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005515 | • GO:0005737 |
| • GO:0005829 | • GO:0046872 |
Pathways
• Androgen receptor signaling pathway
• Cellular response to hormone stimulus
Protein Summary
The AIG1 protein (UniProt Q9Y4K1) is a 347-amino acid protein with unknown molecular function. It is predicted to be cytoplasmic and may interact with metal ions. Expression is induced by androgens, suggesting a role in hormone-regulated cellular processes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| AIG1 Knockout HEK293 Cell Line | EDJ-KQ11079 | Human | 51390 | Details Get a Quote |
| AIG1 Knockout HCT 116 Cell Line | EDJ-KQ39011 | Human | 51390 | Details Get a Quote |
| AIG1 Knockout HeLa Cell Line | EDJ-KQ39012 | Human | 51390 | Details Get a Quote |
| AIG1 Knockout A-549 Cell Line | EDJ-KQ37708 | Human | 51390 | Details Get a Quote |
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