AGFG2 Gene - ArfGAP With FG Repeats 2 | Function, Expression & Disease

AGFG2 (ArfGAP With FG Repeats 2) encodes a protein that belongs to the FG-repeat-containing nucleoporin family. It functions as an ArfGAP (GTPase-activating protein for ADP-ribosylation factor) and is involved in vesicle-mediated transport, RNA export from the nucleus, and HIV-1 Rev-mediated viral RNA export. The protein localizes to the nuclear pore complex and interacts with the HIV-1 Rev protein to facilitate nuclear export of unspliced viral RNA. AGFG2 also plays roles in endosomal trafficking and cell signaling.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• HIV-1 Rev-mediated nuclear export of viral RNA

• Arf6 signaling pathway

• Endosomal recycling pathway

AGFG2 is a 563-amino-acid protein containing an N-terminal ArfGAP domain, a central region with multiple FG (Phe-Gly) repeats, and a C-terminal domain. It acts as a GTPase-activating protein for Arf1 and Arf6, regulating vesicle budding and trafficking. The FG repeats mediate binding to the nuclear pore complex and to HIV-1 Rev, enabling nuclear export of viral RNA. AGFG2 is also implicated in endosomal sorting and cell migration. Its expression is enriched in testis and certain cancers, where it may contribute to tumor progression.