ADM5 Gene - Adrenomedullin 5
Comprehensive genomic and functional overview of ADM5
Gene Information Card
| Symbol | ADM5 |
|---|---|
| Full Name | adrenomedullin 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000205755 |
| UniProt ID | Q5T4F7 |
| OMIM ID | 619206 |
| HGNC ID | 37247 |
| Aliases | ADM5, dJ1009E24.1 |
Description
ADM5 (adrenomedullin 5) is a protein-coding gene located on chromosome 19q13.33. It belongs to the adrenomedullin family of peptides involved in vasodilation and cellular signaling. The gene encodes a precursor protein that is processed to produce a mature peptide with potential roles in cardiovascular regulation and neuroendocrine function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypertension | ADM5 peptide may modulate vascular tone via receptor binding; dysregulation linked to elevated blood pressure | Limited evidence from association studies; not yet confirmed in large cohorts |
| Cardiovascular disease | Potential involvement in vasodilation and cardiac function | Inferred from family member ADM; direct evidence for ADM5 is sparse |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adrenal gland | 0.8 | Low |
| Heart | 0.5 | Low |
| Lung | 0.3 | Low |
| Kidney | 0.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.2 | Low expression |
| HUVEC | 0.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | 0.001% | Unknown effect; predicted benign by in silico tools |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005179 (hormone activity) | • GO:0005576 (extracellular region) |
| • GO:0005615 (extracellular space) |
Pathways
• Adrenomedullin signaling pathway (Reactome: R-HSA-444473)
Protein Summary
The ADM5 protein is a 185-amino-acid precursor that is cleaved to produce a mature adrenomedullin-like peptide. It shares structural homology with adrenomedullin (ADM) and is predicted to bind to calcitonin receptor-like receptor (CALCRL) with receptor activity-modifying proteins (RAMPs), modulating vasodilation and cellular proliferation. Expression is low in most tissues, with highest levels in adrenal gland.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ADM5 Knockout HEK293 Cell Line | EDJ-KQ11707 | Human | 199800 | Details Get a Quote |
| ADM5 Knockout A-549 Cell Line | EDJ-KQ40048 | Human | 199800 | Details Get a Quote |
| ADM5 Knockout HCT 116 Cell Line | EDJ-KQ40049 | Human | 199800 | Details Get a Quote |
| ADM5 Knockout HeLa Cell Line | EDJ-KQ40050 | Human | 199800 | Details Get a Quote |
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