ADIG Gene (Adipogenin)
Adipogenesis regulator and potential biomarker
Gene Information Card
| Symbol | ADIG |
|---|---|
| Full Name | Adipogenin |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 149961 ncbi.nlm.nih.gov/gene/149961 |
| Ensembl ID | ENSG00000187601 |
| UniProt ID | Q5VY09 |
| OMIM ID | 615762 |
| HGNC ID | 26889 |
| Aliases | C1orf55, PPARG-dependent gene |
Description
ADIG (adipogenin) is a protein-coding gene located on chromosome 1p36.33. It is involved in adipogenesis, the process by which preadipocytes differentiate into mature adipocytes. ADIG expression is induced during adipocyte differentiation and is regulated by PPARG. The protein localizes to lipid droplets and may play a role in lipid storage and metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | ADIG expression correlates with adipocyte differentiation; dysregulation may contribute to adipose tissue dysfunction | PMID: 19435877 |
| Type 2 Diabetes | Altered ADIG expression in adipose tissue linked to insulin resistance | PMID: 19435877 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 12.5 | Medium |
| Breast | 1.2 | Low |
| Liver | 0.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| 3T3-L1 (mouse preadipocyte) | N/A | Induced during differentiation; human data limited |
| SGBS (human preadipocyte) | N/A | Upregulated during adipogenesis |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | SNV | <0.01% | Likely benign; no known pathogenic variants in ClinVar |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • lipid droplet organization | • adipocyte differentiation |
| • lipid storage |
Pathways
• PPAR signaling pathway
• Adipogenesis
Protein Summary
Adipogenin is a small protein (approximately 10 kDa) that localizes to lipid droplets in adipocytes. It is induced during adipogenesis and may facilitate lipid droplet formation and stabilization. Its expression is regulated by PPARG, a master regulator of adipocyte differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ADIG Knockout HEK293 Cell Line | EDJ-KQ10522 | Human | 149685 | Details Get a Quote |
| ADIG Knockout HeLa Cell Line | EDJ-KQ58639 | Human | 149685 | Details Get a Quote |
| ADIG Knockout A-549 Cell Line | EDJ-KQ67121 | Human | 149685 | Details Get a Quote |
| ADIG Knockout HCT 116 Cell Line | EDJ-KQ75527 | Human | 149685 | Details Get a Quote |
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