ADGRL2 Gene: Adhesion G Protein-Coupled Receptor L2 | NCBI, UniProt, OMIM

ADGRL2 (Adhesion G Protein-Coupled Receptor L2), also known as LPHN2 (latrophilin 2), is a member of the adhesion G protein-coupled receptor (GPCR) family. It is characterized by a large extracellular N-terminal region containing multiple domains, including a lectin-like domain, an olfactomedin-like domain, and a hormone-binding domain. ADGRL2 is involved in cell adhesion, signaling, and synaptic function. It is expressed in various tissues, particularly in the brain, and has been implicated in neurodevelopmental disorders and cancer.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• GPCR signaling

• Cell adhesion molecules (CAMs)

• Neuroactive ligand-receptor interaction

ADGRL2 encodes a 1,461-amino-acid protein (UniProt O95490) that belongs to the adhesion GPCR family. The protein contains an N-terminal signal peptide, a lectin-like domain, an olfactomedin-like domain, a hormone-binding domain, a GPCR proteolytic site (GPS), and a seven-transmembrane domain. It is involved in cell-cell adhesion and intracellular signaling, particularly in the nervous system. The protein undergoes autoproteolytic cleavage at the GPS motif, producing an N-terminal fragment (NTF) and a C-terminal fragment (CTF) that remain non-covalently associated.