ADGRG4 (Adhesion G Protein-Coupled Receptor G4)
A member of the adhesion GPCR family with roles in cell adhesion and signaling, implicated in immune function and cancer.
Gene Information Card
| Symbol | ADGRG4 |
|---|---|
| Full Name | Adhesion G Protein-Coupled Receptor G4 |
| Gene Type | Protein coding |
| Chromosomal Location | Xq26.3 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000147133 |
| UniProt ID | Q8IZF7 |
| OMIM ID | 300920 |
| HGNC ID | 4510 |
| Aliases | GPR112, PGR18 |
Description
ADGRG4 (Adhesion G Protein-Coupled Receptor G4) encodes a member of the adhesion G protein-coupled receptor (GPCR) family. These receptors are characterized by a large extracellular N-terminal domain with multiple adhesion-like motifs, mediating cell-cell and cell-matrix interactions. ADGRG4 is expressed in immune tissues and has been implicated in immune regulation and cancer progression. The gene is located on the X chromosome.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Altered expression may influence tumor microenvironment and metastasis; limited functional studies | COSMIC, literature |
| Colorectal cancer | Upregulation observed in some studies; potential role in cell adhesion and signaling | COSMIC, literature |
| Immune-related disorders | Expression in lymphoid tissues suggests involvement in immune modulation; not yet validated in large cohorts | NCBI, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.7 | Low |
| Testis | 6.3 | Low |
| Prostate | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (leukemia) | 15.3 | Moderate expression |
| HeLa (cervical cancer) | 3.2 | Low expression |
| A549 (lung cancer) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.1% (COSMIC) | Unknown; predicted possibly damaging |
| c.5678G>A (p.Gly1893Asp) | Missense | <0.1% (COSMIC) | Unknown; predicted benign |
| c.7890_7891insA | Frameshift | <0.01% (COSMIC) | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.7890_7891insA) likely result in truncated, non-functional receptor.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway | • cell adhesion |
| • plasma membrane | • integral component of membrane |
| • receptor activity |
Pathways
• GPCR signaling
• Cell adhesion molecules (CAMs)
Protein Summary
ADGRG4 is a 7-transmembrane adhesion GPCR with a large extracellular region containing multiple thrombospondin type 1 repeats and a GPS (GPCR proteolysis site) domain. It undergoes autoproteolytic cleavage at the GPS motif, producing an N-terminal fragment (NTF) and a C-terminal fragment (CTF) that remain non-covalently associated. The protein is involved in cell adhesion and signaling, with expression enriched in immune tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ADGRG4 Knockout HEK293 Cell Line | EDJ-KQ9542 | Human | 139378 | Details Get a Quote |
| ADGRG4 Knockout HeLa Cell Line | EDJ-KQ58411 | Human | 139378 | Details Get a Quote |
| ADGRG4 Knockout A-549 Cell Line | EDJ-KQ66900 | Human | 139378 | Details Get a Quote |
| ADGRG4 Knockout HCT 116 Cell Line | EDJ-KQ75303 | Human | 139378 | Details Get a Quote |
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